| SP | Tiant, L.Tiant, Luis $ >> | 28 | 1968 | R | 97 | 30 | 30 | 14 | 10 | 3.88 | .309 | 1.31 | 7.9 | 3.9 | 8.3 | 211.1 | 186 | 101 | 91 | 25 | 91 | 194 | 4 | 0 | 0 | 2 | 17 | 6 | 2 | 4.08 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 30 | 30 | 15 | 11 | 4.90 | .325 | 1.43 | 8.7 | 4.2 | 7.9 | 181.2 | 175 | 109 | 99 | 24 | 84 | 159 | 1 | 0 | 0 | 1 | 16 | 4 | 7 | 4.43 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 28 | 28 | 12 | 6 | 4.54 | .310 | 1.32 | 8.7 | 3.2 | 8.2 | 170.2 | 165 | 91 | 86 | 19 | 60 | 155 | 0 | 0 | 0 | 0 | 14 | 5 | 4 | 3.78 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 77 | 29 | 29 | 8 | 14 | 4.89 | .304 | 1.30 | 9.4 | 2.3 | 5.8 | 193.1 | 202 | 112 | 105 | 30 | 50 | 125 | 6 | 0 | 0 | 0 | 13 | 1 | 5 | 4.52 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 65 | 0 | 2 | 2 | 2.12 | .257 | 1.01 | 5.8 | 3.3 | 8.3 | 85.0 | 55 | 21 | 20 | 7 | 31 | 78 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.40 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 36 | 0 | 2 | 2 | 3.92 | .255 | 1.00 | 7.6 | 1.4 | 8.8 | 39.0 | 33 | 17 | 17 | 8 | 6 | 38 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.26 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 22 | 0 | 2 | 0 | 3.05 | .340 | 1.55 | 7.2 | 7.2 | 8.6 | 20.2 | 16 | 9 | 7 | 2 | 16 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.80 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 38 | 0 | 0 | 4 | 6.00 | .344 | 1.57 | 10.7 | 3.4 | 9.2 | 42.0 | 50 | 28 | 28 | 11 | 16 | 43 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 5.50 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 21 | 1 | 6 | 0 | 3.21 | .294 | 1.22 | 7.4 | 3.6 | 5.6 | 95.1 | 78 | 37 | 34 | 13 | 38 | 59 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.83 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 55 | 0 | 6 | 5 | 1.75 | .244 | 0.97 | 6.4 | 2.4 | 7.7 | 56.2 | 40 | 12 | 11 | 4 | 15 | 48 | 0 | 34 | 2 | 0 | 0 | 0 | 0 | 3.02 |