| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 30 | 30 | 14 | 11 | 3.63 | .284 | 1.17 | 8.0 | 2.6 | 7.6 | 228.1 | 202 | 98 | 92 | 25 | 65 | 193 | 9 | 0 | 0 | 1 | 16 | 5 | 1 | 3.65 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 29 | 29 | 12 | 13 | 4.67 | .302 | 1.29 | 8.9 | 2.8 | 5.3 | 206.1 | 203 | 112 | 107 | 39 | 64 | 122 | 11 | 0 | 0 | 1 | 14 | 1 | 4 | 5.22 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 28 | 28 | 7 | 12 | 4.78 | .336 | 1.49 | 9.8 | 3.6 | 4.4 | 192.0 | 210 | 107 | 102 | 22 | 76 | 94 | 2 | 0 | 0 | 0 | 11 | 5 | 4 | 4.78 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 75 | 0 | 3 | 0 | 1.62 | .254 | 0.98 | 5.8 | 3.1 | 9.6 | 72.1 | 46 | 17 | 13 | 3 | 25 | 77 | 0 | 0 | 3 | 0 | 0 | 3 | 1 | 2.57 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 50 | 0 | 3 | 6 | 3.67 | .305 | 1.31 | 7.7 | 4.2 | 8.5 | 54.0 | 46 | 23 | 22 | 7 | 25 | 51 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 4.19 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 36 | 0 | 2 | 3 | 6.94 | .374 | 1.79 | 12.8 | 3.5 | 9.0 | 36.1 | 51 | 31 | 28 | 6 | 14 | 36 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.33 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 40 | 0 | 2 | 1 | 3.02 | .333 | 1.48 | 7.8 | 5.7 | 8.2 | 44.2 | 38 | 16 | 15 | 5 | 28 | 40 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.64 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |