| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 30 | 30 | 10 | 11 | 3.39 | .272 | 1.11 | 7.6 | 2.4 | 7.8 | 199.1 | 167 | 75 | 75 | 24 | 54 | 172 | 3 | 0 | 0 | 3 | 18 | 2 | 3 | 3.68 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 29 | 29 | 17 | 9 | 3.04 | .277 | 1.13 | 6.5 | 3.7 | 4.7 | 189.2 | 137 | 67 | 64 | 15 | 78 | 98 | 4 | 0 | 0 | 1 | 21 | 3 | 4 | 4.28 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 86 | 29 | 29 | 14 | 7 | 3.42 | .261 | 1.05 | 7.5 | 1.9 | 5.1 | 192.0 | 160 | 75 | 73 | 15 | 41 | 109 | 0 | 0 | 0 | 0 | 20 | 2 | 4 | 3.55 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 29 | 29 | 21 | 4 | 2.73 | .272 | 1.10 | 6.9 | 3.0 | 7.7 | 191.1 | 146 | 60 | 58 | 13 | 64 | 164 | 0 | 0 | 0 | 0 | 22 | 5 | 4 | 3.25 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 41 | 26 | 26 | 9 | 11 | 4.67 | .338 | 1.52 | 9.8 | 3.8 | 8.0 | 152.1 | 166 | 85 | 79 | 15 | 65 | 135 | 0 | 0 | 0 | 0 | 11 | 2 | 6 | 3.83 |
| RP | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 81 | 0 | 5 | 2 | 2.98 | .262 | 1.05 | 5.6 | 3.9 | 10.2 | 108.2 | 67 | 36 | 36 | 6 | 47 | 122 | 0 | 14 | 3 | 0 | 0 | 2 | 4 | 2.82 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 74 | 0 | 1 | 5 | 3.19 | .292 | 1.22 | 10.0 | 1.0 | 7.6 | 93.0 | 103 | 33 | 33 | 12 | 10 | 79 | 0 | 11 | 5 | 0 | 0 | 2 | 0 | 3.37 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 33 | 0 | 2 | 2 | 2.48 | .268 | 1.10 | 5.5 | 4.5 | 8.3 | 36.1 | 22 | 11 | 10 | 2 | 18 | 33 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.39 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 7 | 0 | 0 | 2 | 7.20 | .268 | 1.00 | 6.3 | 2.7 | 12.6 | 10.0 | 7 | 8 | 8 | 4 | 3 | 14 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 6.60 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 4 | 0 | 1 | 1 | 2.70 | .298 | 1.20 | 6.9 | 4.2 | 6.2 | 13.1 | 10 | 4 | 4 | 0 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.23 |