| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 31 | 31 | 10 | 13 | 2.83 | .263 | 1.05 | 6.9 | 2.5 | 6.0 | 235.1 | 181 | 76 | 74 | 22 | 65 | 157 | 7 | 0 | 0 | 2 | 22 | 6 | 3 | 3.79 |
| SP | Ryan, N.Ryan, Nolan † $ >> | 44 | 1991 | R | 73 | 29 | 29 | 13 | 7 | 2.89 | .271 | 1.11 | 6.1 | 3.9 | 7.4 | 208.1 | 142 | 73 | 67 | 24 | 89 | 172 | 3 | 0 | 0 | 0 | 21 | 1 | 7 | 4.14 |
| SP | McDowell, S.McDowell, Sam † >> | 23 | 1965 | L | 44 | 26 | 26 | 15 | 8 | 3.44 | .302 | 1.28 | 6.4 | 5.2 | 7.5 | 167.2 | 119 | 65 | 64 | 7 | 96 | 140 | 2 | 0 | 0 | 1 | 16 | 3 | 5 | 3.65 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 71 | 0 | 6 | 4 | 2.75 | .271 | 1.09 | 6.6 | 3.3 | 8.1 | 104.2 | 76 | 34 | 32 | 8 | 38 | 94 | 0 | 9 | 0 | 0 | 0 | 3 | 0 | 3.38 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 45 | 0 | 2 | 5 | 4.13 | .284 | 1.19 | 7.1 | 3.6 | 4.9 | 48.0 | 38 | 31 | 22 | 10 | 19 | 26 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 5.81 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 22 | 0 | 2 | 0 | 2.74 | .281 | 1.17 | 7.0 | 3.5 | 5.9 | 23.0 | 18 | 9 | 7 | 1 | 9 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.43 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 44 | 10 | 0 | 1 | 2 | 3.77 | .246 | 0.98 | 3.9 | 5.1 | 7.1 | 14.1 | 6 | 6 | 6 | 0 | 8 | 11 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.14 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 7 | 0 | 0 | 0 | 3.00 | .379 | 1.83 | 12.0 | 4.5 | 6.0 | 6.0 | 8 | 2 | 2 | 1 | 3 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.33 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 12 | 0 | 0 | 1 | 3.46 | .291 | 1.23 | 7.6 | 3.5 | 9.7 | 13.0 | 11 | 5 | 5 | 1 | 5 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |