| SP | Drabek, D.Drabek, Doug >> | 26 | 1988 | R | 93 | 16 | 16 | 6 | 4 | 2.94 | .303 | 1.29 | 8.9 | 2.7 | 5.1 | 113.1 | 112 | 38 | 37 | 4 | 34 | 64 | 2 | 0 | 0 | 0 | 14 | 2 | 3 | 3.28 |
| SP | Guthrie, J.Guthrie, Jeremy >> | 28 | 2007 | R | 75 | 16 | 16 | 2 | 7 | 4.88 | .300 | 1.27 | 8.8 | 2.6 | 4.8 | 94.0 | 92 | 53 | 51 | 11 | 27 | 50 | 0 | 0 | 0 | 0 | 7 | 2 | 3 | 4.38 |
| SP | Mahaffey, A.Mahaffey, Art >> | 23 | 1961 | R | 69 | 15 | 15 | 5 | 5 | 5.65 | .329 | 1.46 | 10.9 | 2.4 | 5.7 | 87.2 | 105 | 57 | 55 | 11 | 23 | 55 | 0 | 0 | 0 | 0 | 7 | 1 | 2 | 4.21 |
| SP | Astacio, P.Astacio, Pedro # >> | 28 | 1997 | R | 55 | 15 | 15 | 9 | 4 | 4.52 | .333 | 1.46 | 9.6 | 3.7 | 5.9 | 93.2 | 99 | 52 | 47 | 9 | 38 | 61 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 4.27 |
| SP | Mercker, K.Mercker, Kent >> | 27 | 1995 | L | 38 | 15 | 15 | 4 | 4 | 4.88 | .331 | 1.49 | 10.0 | 3.4 | 5.2 | 79.1 | 88 | 45 | 43 | 10 | 30 | 46 | 0 | 0 | 0 | 0 | 4 | 0 | 4 | 4.62 |
| RP | De Los Santos, E.De Los Santos, Enyel >> | 26 | 2022 | R | 94 | 37 | 0 | 2 | 4 | 4.93 | .336 | 1.52 | 8.8 | 5.0 | 8.8 | 49.1 | 48 | 30 | 27 | 4 | 27 | 48 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.76 |
| RP | Tepera, R.Tepera, Ryan >> | 30 | 2018 | R | 76 | 45 | 0 | 5 | 0 | 4.55 | .317 | 1.40 | 9.2 | 3.5 | 8.5 | 57.1 | 58 | 32 | 29 | 5 | 22 | 54 | 0 | 4 | 5 | 0 | 0 | 0 | 3 | 3.40 |
| RP | Timlin, M.Timlin, Mike >> | 31 | 1997 | R | 55 | 34 | 0 | 1 | 2 | 4.31 | .328 | 1.46 | 10.4 | 3.0 | 7.8 | 39.2 | 45 | 21 | 19 | 5 | 13 | 34 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 3.92 |
| RP | Wendell, T.Wendell, Turk >> | 34 | 2001 | R | 39 | 32 | 0 | 3 | 5 | 5.91 | .364 | 1.66 | 9.8 | 5.1 | 5.3 | 32.0 | 35 | 23 | 21 | 4 | 18 | 19 | 0 | 1 | 3 | 0 | 0 | 2 | 1 | 5.31 |
| RP | Coleman, J.Coleman, Joe >> | 31 | 1978 | R | 27 | 24 | 0 | 0 | 3 | 5.23 | .347 | 1.53 | 12.4 | 1.7 | 4.5 | 32.2 | 44 | 19 | 19 | 4 | 6 | 16 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 4.38 |
| SP | Blanton, C.Blanton, Cy >> | 29 | 1937 | R | 37 | 9 | 0 | 1 | 1 | 6.75 | .385 | 1.88 | 11.1 | 6.2 | 5.5 | 13.1 | 16 | 10 | 10 | 1 | 9 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.85 |