| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 98 | 34 | 34 | 13 | 16 | 3.82 | .271 | 1.10 | 8.0 | 1.9 | 8.8 | 252.0 | 223 | 118 | 107 | 34 | 54 | 247 | 11 | 0 | 0 | 2 | 21 | 4 | 5 | 3.48 |
| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 97 | 32 | 32 | 10 | 13 | 4.84 | .323 | 1.42 | 9.2 | 3.6 | 9.8 | 187.2 | 191 | 110 | 101 | 29 | 75 | 204 | 1 | 0 | 0 | 0 | 15 | 2 | 4 | 4.07 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 89 | 32 | 32 | 15 | 12 | 3.06 | .284 | 1.15 | 7.8 | 2.6 | 9.5 | 235.2 | 204 | 92 | 80 | 23 | 68 | 248 | 3 | 0 | 0 | 0 | 23 | 9 | 8 | 3.14 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 58 | 30 | 30 | 7 | 15 | 6.01 | .362 | 1.68 | 9.7 | 5.5 | 6.4 | 178.1 | 191 | 126 | 119 | 30 | 108 | 127 | 0 | 0 | 0 | 0 | 13 | 4 | 2 | 5.65 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 85 | 101 | 0 | 1 | 2 | 3.38 | .267 | 1.06 | 7.8 | 1.8 | 8.7 | 98.2 | 85 | 37 | 37 | 10 | 20 | 95 | 0 | 14 | 3 | 0 | 0 | 3 | 0 | 3.09 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 75 | 0 | 3 | 1 | 2.93 | .292 | 1.24 | 6.8 | 4.5 | 10.4 | 76.2 | 57 | 32 | 25 | 10 | 38 | 88 | 0 | 13 | 3 | 0 | 0 | 0 | 0 | 3.89 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 43 | 0 | 4 | 6 | 4.47 | .352 | 1.59 | 11.9 | 2.5 | 8.1 | 50.1 | 66 | 26 | 25 | 10 | 14 | 45 | 0 | 4 | 3 | 0 | 0 | 2 | 5 | 4.76 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 64 | 32 | 0 | 1 | 5 | 4.46 | .299 | 1.28 | 8.5 | 3.2 | 11.6 | 34.1 | 32 | 17 | 17 | 4 | 12 | 44 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 55 | 26 | 0 | 0 | 3 | 5.00 | .386 | 1.85 | 10.3 | 6.3 | 8.0 | 27.0 | 31 | 19 | 15 | 8 | 19 | 24 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 7.30 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 51 | 8 | 2 | 4 | 2 | 7.20 | .384 | 1.87 | 11.4 | 5.4 | 7.8 | 15.0 | 19 | 12 | 12 | 3 | 9 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.67 |