| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 10 | 10 | 3 | 3 | 2.95 | .307 | 1.28 | 8.6 | 3.0 | 7.9 | 64.0 | 61 | 21 | 21 | 6 | 21 | 56 | 2 | 0 | 0 | 0 | 7 | 3 | 3 | 3.59 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 9 | 9 | 1 | 2 | 7.29 | .375 | 1.77 | 11.7 | 4.4 | 9.0 | 33.1 | 43 | 27 | 27 | 6 | 16 | 33 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.91 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 68 | 10 | 9 | 3 | 4 | 5.37 | .356 | 1.60 | 11.5 | 3.1 | 7.8 | 53.2 | 68 | 35 | 32 | 6 | 18 | 46 | 0 | 0 | 0 | 0 | 5 | 3 | 0 | 3.92 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 20 | 0 | 1 | 0 | 3.32 | .278 | 1.15 | 6.9 | 3.9 | 6.9 | 21.2 | 16 | 8 | 8 | 1 | 9 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 18 | 0 | 2 | 0 | 3.38 | .339 | 1.54 | 9.7 | 4.5 | 9.0 | 26.2 | 28 | 10 | 10 | 0 | 13 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.50 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 20 | 0 | 1 | 2 | 7.06 | .309 | 1.34 | 6.9 | 5.6 | 10.3 | 21.2 | 16 | 17 | 17 | 2 | 13 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 3.81 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 71 | 18 | 0 | 0 | 0 | 4.00 | .379 | 1.72 | 9.5 | 6.0 | 13.0 | 18.0 | 19 | 8 | 8 | 2 | 12 | 26 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.89 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 68 | 13 | 0 | 2 | 0 | 5.40 | .322 | 1.35 | 9.0 | 3.5 | 6.2 | 13.1 | 13 | 9 | 8 | 1 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.00 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 66 | 11 | 0 | 1 | 0 | 4.50 | .348 | 1.60 | 7.2 | 7.2 | 7.2 | 10.0 | 8 | 5 | 5 | 1 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.10 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 25 | 0 | 1 | 2 | 3.51 | .214 | 0.82 | 4.7 | 2.9 | 10.4 | 25.2 | 13 | 10 | 10 | 6 | 8 | 29 | 0 | 14 | 1 | 0 | 0 | 0 | 1 | 4.76 |