| SP | Greinke, Z.Greinke, Zack # >> | 32 | 2015 | R | 93 | 19 | 19 | 7 | 7 | 4.07 | .285 | 1.14 | 7.9 | 2.4 | 7.2 | 132.2 | 116 | 60 | 60 | 22 | 35 | 106 | 1 | 0 | 0 | 0 | 11 | 8 | 0 | 4.54 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 77 | 19 | 19 | 4 | 7 | 6.22 | .349 | 1.61 | 11.1 | 3.4 | 6.9 | 111.1 | 137 | 81 | 77 | 25 | 42 | 85 | 1 | 0 | 0 | 0 | 6 | 0 | 2 | 5.53 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 18 | 18 | 2 | 9 | 7.48 | .389 | 1.89 | 12.6 | 4.3 | 8.1 | 89.0 | 125 | 76 | 74 | 16 | 43 | 80 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 5.06 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 49 | 0 | 0 | 3 | 3.93 | .313 | 1.35 | 6.8 | 5.6 | 8.2 | 68.2 | 51 | 33 | 30 | 9 | 42 | 62 | 0 | 5 | 3 | 0 | 0 | 1 | 2 | 4.79 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 44 | 0 | 5 | 2 | 4.23 | .299 | 1.28 | 9.0 | 2.7 | 10.3 | 61.2 | 61 | 29 | 29 | 11 | 18 | 70 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 3.93 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 42 | 0 | 5 | 1 | 2.95 | .266 | 1.09 | 5.3 | 4.5 | 8.7 | 58.0 | 34 | 19 | 19 | 6 | 29 | 56 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 3.91 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 54 | 37 | 0 | 3 | 4 | 4.40 | .289 | 1.22 | 8.0 | 3.0 | 8.8 | 45.0 | 40 | 22 | 22 | 9 | 15 | 44 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 4.64 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 46 | 25 | 0 | 3 | 0 | 4.28 | .274 | 1.13 | 8.0 | 2.3 | 10.0 | 27.1 | 24 | 13 | 13 | 3 | 7 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 56 | 2 | 0 | 0 | 0 | 0.00 | .421 | 2.18 | 15.0 | 9.0 | 18.0 | 3.2 | 5 | 3 | 0 | 2 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.67 |