| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 97 | 21 | 21 | 8 | 9 | 3.42 | .285 | 1.13 | 8.5 | 1.7 | 9.9 | 134.1 | 127 | 54 | 51 | 10 | 25 | 147 | 2 | 0 | 0 | 0 | 15 | 9 | 1 | 2.54 |
| SP | Manoah, A.Manoah, Alek >> | 24 | 2022 | R | 85 | 20 | 20 | 7 | 6 | 5.16 | .335 | 1.43 | 9.4 | 3.6 | 7.2 | 118.2 | 123 | 69 | 68 | 15 | 47 | 95 | 0 | 0 | 0 | 0 | 10 | 9 | 4 | 4.47 |
| SP | Wheeler, Z.Wheeler, Zack # >> | 32 | 2022 | R | 82 | 19 | 19 | 6 | 5 | 3.36 | .287 | 1.19 | 8.0 | 2.8 | 9.8 | 120.2 | 106 | 45 | 45 | 9 | 37 | 131 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 2.79 |
| SP | Musgrove, J.Musgrove, Joseph >> | 29 | 2022 | R | 75 | 19 | 19 | 9 | 7 | 4.42 | .310 | 1.26 | 9.0 | 2.4 | 8.7 | 114.0 | 114 | 56 | 56 | 14 | 30 | 110 | 0 | 0 | 0 | 0 | 10 | 10 | 2 | 3.72 |
| SP | Bassitt, C.Bassitt, Chris >> | 33 | 2022 | R | 64 | 18 | 18 | 6 | 8 | 5.01 | .345 | 1.51 | 10.3 | 3.4 | 7.7 | 102.1 | 117 | 60 | 57 | 14 | 38 | 87 | 0 | 0 | 0 | 0 | 6 | 7 | 5 | 4.40 |
| CL | Diaz, A.Diaz, Alexis † >> | 25 | 2022 | R | 93 | 37 | 0 | 1 | 2 | 1.76 | .206 | 0.73 | 3.7 | 2.9 | 9.9 | 41.0 | 17 | 8 | 8 | 3 | 13 | 45 | 0 | 28 | 1 | 0 | 0 | 2 | 1 | 2.85 |
| SU | Hentges, S.Hentges, Sam >> | 25 | 2022 | L | 90 | 45 | 0 | 2 | 0 | 3.67 | .324 | 1.39 | 9.2 | 3.5 | 10.5 | 41.2 | 42 | 17 | 17 | 7 | 16 | 48 | 0 | 1 | 4 | 0 | 0 | 2 | 0 | 4.20 |
| RP | Karinchak, J.Karinchak, James >> | 26 | 2022 | R | 83 | 53 | 0 | 5 | 2 | 3.50 | .328 | 1.41 | 6.7 | 6.0 | 10.5 | 54.0 | 40 | 21 | 21 | 4 | 36 | 63 | 0 | 0 | 3 | 0 | 0 | 3 | 4 | 3.80 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 30 | 2022 | R | 79 | 47 | 0 | 4 | 1 | 3.27 | .327 | 1.39 | 8.2 | 4.3 | 12.3 | 44.0 | 40 | 17 | 16 | 5 | 21 | 60 | 0 | 5 | 2 | 0 | 0 | 3 | 1 | 3.39 |
| RP | Montero, R.Montero, Rafael >> | 31 | 2022 | R | 76 | 36 | 0 | 3 | 1 | 5.56 | .329 | 1.35 | 9.3 | 2.9 | 9.5 | 34.0 | 35 | 21 | 21 | 6 | 11 | 36 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 4.50 |
| RP | Leclerc, J.Leclerc, Jose >> | 28 | 2022 | R | 71 | 23 | 0 | 0 | 2 | 3.04 | .298 | 1.28 | 7.6 | 4.2 | 6.2 | 26.2 | 22 | 10 | 9 | 1 | 12 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.50 |
| RP | Alvarado, J.Alvarado, Jose >> | 27 | 2022 | L | 63 | 50 | 0 | 1 | 2 | 3.86 | .327 | 1.34 | 9.5 | 2.6 | 10.8 | 35.0 | 37 | 15 | 15 | 3 | 10 | 42 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2.91 |