| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 98 | 20 | 20 | 4 | 10 | 4.05 | .298 | 1.22 | 7.5 | 3.6 | 11.1 | 126.2 | 105 | 57 | 57 | 17 | 50 | 156 | 0 | 0 | 0 | 0 | 11 | 6 | 6 | 3.61 |
| SP | Luzardo, J.Luzardo, Jesus >> | 24 | 2022 | L | 87 | 20 | 20 | 6 | 7 | 3.72 | .298 | 1.26 | 8.7 | 2.7 | 10.4 | 118.2 | 114 | 51 | 49 | 11 | 35 | 136 | 0 | 0 | 0 | 0 | 10 | 2 | 3 | 2.85 |
| SP | Stripling, R.Stripling, Ross # >> | 32 | 2022 | R | 72 | 19 | 19 | 4 | 6 | 3.89 | .288 | 1.18 | 8.3 | 2.4 | 6.5 | 88.0 | 81 | 38 | 38 | 8 | 23 | 64 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 3.61 |
| SP | Skubal, T.Skubal, Tarik >> | 25 | 2022 | L | 61 | 19 | 19 | 4 | 10 | 7.11 | .357 | 1.60 | 11.5 | 2.9 | 9.1 | 101.1 | 129 | 80 | 80 | 24 | 33 | 102 | 0 | 0 | 0 | 0 | 3 | 7 | 0 | 5.26 |
| SP | Morton, C.Morton, Charlie >> | 39 | 2022 | R | 57 | 19 | 19 | 6 | 9 | 4.89 | .331 | 1.43 | 9.3 | 3.7 | 10.2 | 106.2 | 109 | 58 | 58 | 17 | 43 | 120 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 4.21 |
| RP | Helsley, R.Helsley, Ryan >> | 27 | 2022 | R | 100 | 48 | 0 | 3 | 1 | 3.49 | .296 | 1.25 | 6.0 | 5.3 | 11.2 | 69.2 | 46 | 28 | 27 | 7 | 41 | 86 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 3.65 |
| RP | Neris, H.Neris, Hector >> | 33 | 2022 | R | 78 | 50 | 0 | 4 | 3 | 2.67 | .292 | 1.19 | 7.6 | 3.1 | 12.2 | 64.0 | 54 | 20 | 19 | 5 | 22 | 87 | 0 | 2 | 3 | 0 | 0 | 3 | 9 | 2.47 |
| RP | Farmer, B.Farmer, Buck >> | 31 | 2022 | R | 46 | 37 | 0 | 1 | 1 | 4.12 | .335 | 1.51 | 9.2 | 4.6 | 12.1 | 43.2 | 44 | 20 | 20 | 7 | 22 | 58 | 0 | 4 | 3 | 0 | 0 | 0 | 3 | 3.95 |
| RP | Garcia, J.Garcia, Jarlin >> | 29 | 2022 | L | 38 | 34 | 0 | 1 | 4 | 2.62 | .287 | 1.19 | 9.2 | 1.6 | 7.8 | 44.2 | 45 | 14 | 13 | 5 | 8 | 38 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.36 |
| SP | Quantrill, C.Quantrill, Cal >> | 27 | 2022 | R | 40 | 1 | 0 | 0 | 1 | 3.00 | .250 | 1.00 | 6.0 | 3.0 | 3.0 | 3.0 | 2 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.33 |