| SP | Burnes, C.Burnes, Corbin >> | 27 | 2022 | R | 94 | 18 | 18 | 6 | 7 | 4.16 | .310 | 1.26 | 8.8 | 2.6 | 10.0 | 101.2 | 99 | 48 | 47 | 11 | 29 | 112 | 0 | 0 | 0 | 0 | 9 | 9 | 5 | 3.33 |
| SP | Alcantara, S.Alcantara, Sandy >> | 26 | 2022 | R | 84 | 17 | 17 | 8 | 7 | 3.61 | .311 | 1.32 | 8.9 | 3.0 | 7.0 | 112.1 | 111 | 48 | 45 | 15 | 37 | 87 | 2 | 0 | 0 | 0 | 9 | 4 | 4 | 4.29 |
| SP | Anderson, T.Anderson, Tyler >> | 32 | 2022 | L | 80 | 16 | 16 | 6 | 6 | 4.29 | .304 | 1.20 | 8.9 | 2.0 | 7.3 | 100.2 | 99 | 50 | 48 | 14 | 22 | 81 | 0 | 0 | 0 | 0 | 10 | 11 | 0 | 4.19 |
| SP | Valdez, F.Valdez, Framber † # >> | 28 | 2022 | L | 71 | 16 | 16 | 10 | 3 | 3.73 | .298 | 1.26 | 8.8 | 2.6 | 9.2 | 101.1 | 99 | 43 | 42 | 14 | 29 | 103 | 1 | 0 | 0 | 0 | 12 | 1 | 2 | 3.65 |
| SP | Wacha, M.Wacha, Michael >> | 30 | 2022 | R | 66 | 16 | 16 | 3 | 4 | 4.03 | .324 | 1.39 | 8.8 | 3.8 | 7.7 | 91.2 | 89 | 45 | 41 | 19 | 38 | 78 | 0 | 0 | 0 | 0 | 7 | 5 | 1 | 5.42 |
| CL | Pressly, R.Pressly, Ryan † >> | 33 | 2022 | R | 95 | 33 | 0 | 2 | 4 | 2.80 | .289 | 1.19 | 7.2 | 3.6 | 8.2 | 35.1 | 28 | 11 | 11 | 2 | 14 | 32 | 0 | 15 | 2 | 0 | 0 | 1 | 0 | 3.20 |
| RP | Herget, J.Herget, Jimmy >> | 28 | 2022 | R | 85 | 49 | 0 | 2 | 1 | 3.68 | .302 | 1.23 | 8.8 | 2.3 | 8.4 | 44.0 | 43 | 18 | 18 | 4 | 11 | 41 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 3.27 |
| RP | Jansen, K.Jansen, Kenley >> | 34 | 2022 | R | 77 | 41 | 0 | 3 | 1 | 5.63 | .342 | 1.53 | 9.0 | 4.8 | 9.6 | 32.0 | 32 | 20 | 20 | 7 | 17 | 34 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.41 |
| RP | Neris, H.Neris, Hector >> | 33 | 2022 | R | 78 | 27 | 0 | 0 | 2 | 3.32 | .337 | 1.52 | 10.3 | 3.9 | 9.9 | 21.2 | 24 | 8 | 8 | 1 | 9 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2.71 |