| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 20 | 20 | 9 | 6 | 3.62 | .302 | 1.24 | 8.1 | 3.1 | 8.0 | 141.2 | 127 | 61 | 57 | 14 | 49 | 125 | 0 | 0 | 0 | 0 | 13 | 8 | 1 | 3.73 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 20 | 20 | 11 | 5 | 3.31 | .288 | 1.20 | 8.6 | 2.2 | 5.0 | 147.0 | 141 | 54 | 54 | 13 | 36 | 81 | 2 | 0 | 0 | 1 | 14 | 1 | 2 | 3.80 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 19 | 19 | 7 | 10 | 4.00 | .303 | 1.27 | 8.2 | 3.3 | 7.1 | 135.0 | 123 | 61 | 60 | 13 | 49 | 106 | 3 | 0 | 0 | 1 | 12 | 4 | 2 | 3.86 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 19 | 19 | 6 | 10 | 4.38 | .307 | 1.31 | 9.5 | 2.4 | 4.9 | 137.2 | 145 | 67 | 67 | 18 | 36 | 75 | 2 | 0 | 0 | 0 | 10 | 2 | 2 | 4.45 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 19 | 19 | 6 | 12 | 5.10 | .338 | 1.50 | 9.9 | 3.6 | 4.8 | 136.0 | 149 | 80 | 77 | 18 | 55 | 72 | 5 | 0 | 0 | 1 | 9 | 4 | 4 | 4.96 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 39 | 0 | 1 | 4 | 3.46 | .264 | 1.08 | 7.6 | 2.1 | 7.8 | 39.0 | 33 | 17 | 15 | 6 | 9 | 34 | 0 | 25 | 3 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 44 | 0 | 2 | 3 | 4.17 | .308 | 1.28 | 6.8 | 5.0 | 5.8 | 36.2 | 27 | 22 | 17 | 5 | 20 | 23 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.36 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 46 | 0 | 2 | 0 | 4.81 | .336 | 1.51 | 8.7 | 5.2 | 7.6 | 33.2 | 32 | 19 | 18 | 4 | 19 | 28 | 0 | 1 | 2 | 0 | 0 | 0 | 6 | 4.61 |