| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 21 | 21 | 8 | 11 | 4.13 | .291 | 1.21 | 6.8 | 4.1 | 5.7 | 124.1 | 94 | 58 | 57 | 11 | 57 | 79 | 0 | 0 | 0 | 0 | 12 | 2 | 1 | 4.31 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 20 | 20 | 13 | 3 | 3.32 | .272 | 1.11 | 8.5 | 1.6 | 3.5 | 143.2 | 135 | 56 | 53 | 11 | 25 | 56 | 7 | 0 | 0 | 0 | 13 | 1 | 2 | 3.76 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 82 | 19 | 19 | 11 | 6 | 3.01 | .250 | 0.96 | 7.0 | 1.7 | 5.4 | 140.1 | 109 | 50 | 47 | 15 | 26 | 84 | 5 | 0 | 0 | 2 | 14 | 5 | 2 | 3.86 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 21 | 19 | 11 | 4 | 3.96 | .298 | 1.26 | 7.3 | 4.0 | 4.3 | 127.1 | 103 | 58 | 56 | 12 | 57 | 60 | 3 | 0 | 0 | 1 | 11 | 2 | 0 | 4.68 |
| RP | Williams, D.Williams, Devin † >> | 28 | 2023 | R | 72 | 55 | 0 | 3 | 2 | 4.07 | .327 | 1.44 | 6.6 | 6.6 | 10.1 | 59.2 | 43 | 30 | 27 | 6 | 43 | 66 | 0 | 8 | 3 | 0 | 0 | 1 | 3 | 4.32 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 42 | 0 | 3 | 1 | 3.42 | .330 | 1.46 | 7.0 | 6.1 | 7.2 | 50.0 | 39 | 24 | 19 | 5 | 34 | 40 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 4.80 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 39 | 0 | 2 | 0 | 1.66 | .266 | 1.07 | 5.1 | 4.7 | 11.4 | 48.2 | 27 | 10 | 9 | 3 | 25 | 61 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 2.90 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 30 | 0 | 2 | 0 | 4.50 | .333 | 1.50 | 9.3 | 4.2 | 9.6 | 28.0 | 29 | 15 | 14 | 2 | 13 | 30 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 3.18 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 22 | 0 | 1 | 2 | 2.70 | .286 | 1.20 | 7.1 | 3.8 | 7.9 | 33.1 | 26 | 18 | 10 | 3 | 14 | 29 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.70 |