| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 21 | 21 | 8 | 3 | 3.42 | .283 | 1.17 | 8.6 | 1.9 | 8.9 | 134.1 | 128 | 54 | 51 | 14 | 29 | 132 | 0 | 0 | 0 | 0 | 13 | 2 | 0 | 3.08 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 20 | 19 | 5 | 8 | 5.08 | .344 | 1.56 | 9.9 | 4.2 | 4.1 | 118.2 | 130 | 70 | 67 | 14 | 55 | 54 | 2 | 0 | 0 | 0 | 8 | 2 | 2 | 5.08 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 19 | 19 | 8 | 7 | 5.77 | .336 | 1.49 | 10.1 | 3.4 | 4.7 | 110.2 | 124 | 77 | 71 | 16 | 41 | 58 | 4 | 0 | 0 | 0 | 7 | 3 | 3 | 5.04 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 20 | 19 | 7 | 8 | 4.39 | .311 | 1.35 | 8.9 | 3.2 | 4.2 | 125.0 | 124 | 65 | 61 | 15 | 45 | 59 | 5 | 0 | 0 | 0 | 8 | 0 | 3 | 4.70 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 63 | 0 | 3 | 4 | 4.55 | .301 | 1.26 | 8.9 | 2.6 | 8.0 | 63.1 | 62 | 35 | 32 | 12 | 18 | 56 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 4.65 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 59 | 0 | 1 | 4 | 5.51 | .317 | 1.39 | 9.7 | 2.9 | 8.6 | 65.1 | 70 | 45 | 40 | 12 | 21 | 62 | 0 | 5 | 3 | 0 | 0 | 0 | 0 | 4.46 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 45 | 0 | 3 | 2 | 4.12 | .336 | 1.52 | 9.0 | 4.8 | 7.8 | 54.2 | 54 | 26 | 25 | 4 | 29 | 47 | 0 | 5 | 1 | 0 | 0 | 0 | 8 | 3.83 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 40 | 0 | 5 | 2 | 5.72 | .349 | 1.57 | 11.0 | 3.2 | 7.6 | 50.1 | 61 | 32 | 32 | 6 | 18 | 42 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.08 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 33 | 0 | 0 | 2 | 4.89 | .331 | 1.46 | 7.2 | 5.9 | 9.3 | 35.0 | 28 | 19 | 19 | 2 | 23 | 36 | 0 | 4 | 1 | 0 | 0 | 1 | 3 | 3.74 |