| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 19 | 19 | 9 | 8 | 3.18 | .276 | 1.10 | 7.5 | 2.5 | 5.0 | 124.1 | 103 | 52 | 44 | 9 | 34 | 69 | 4 | 0 | 0 | 2 | 12 | 5 | 1 | 3.77 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 18 | 18 | 8 | 9 | 3.57 | .303 | 1.30 | 8.9 | 2.7 | 4.9 | 131.0 | 130 | 56 | 52 | 14 | 40 | 72 | 6 | 0 | 0 | 1 | 13 | 1 | 2 | 4.23 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 18 | 18 | 4 | 9 | 6.61 | .374 | 1.75 | 10.2 | 5.7 | 7.2 | 77.2 | 87 | 59 | 57 | 12 | 49 | 62 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 5.44 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 52 | 17 | 17 | 7 | 5 | 5.68 | .337 | 1.51 | 9.9 | 3.8 | 5.9 | 84.0 | 92 | 59 | 53 | 14 | 35 | 55 | 0 | 0 | 0 | 0 | 7 | 1 | 3 | 5.14 |
| SP | Cuellar, M.Cuellar, Mike >> | 32 | 1969 | L | 44 | 18 | 17 | 5 | 9 | 5.83 | .344 | 1.52 | 10.0 | 3.7 | 5.0 | 97.1 | 108 | 70 | 63 | 14 | 40 | 54 | 2 | 0 | 0 | 0 | 5 | 5 | 0 | 5.15 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 52 | 0 | 2 | 4 | 5.96 | .313 | 1.37 | 7.9 | 4.5 | 7.3 | 48.1 | 42 | 33 | 32 | 7 | 24 | 39 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.77 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 53 | 0 | 2 | 2 | 4.02 | .301 | 1.28 | 7.9 | 3.6 | 9.0 | 65.0 | 57 | 34 | 29 | 7 | 26 | 65 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 47 | 0 | 1 | 2 | 4.72 | .331 | 1.46 | 6.7 | 6.5 | 9.2 | 55.1 | 41 | 29 | 29 | 3 | 40 | 56 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.91 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 39 | 0 | 2 | 0 | 5.95 | .323 | 1.38 | 8.0 | 4.3 | 8.0 | 56.0 | 50 | 40 | 37 | 9 | 27 | 50 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 4.91 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 45 | 32 | 0 | 1 | 0 | 3.22 | .306 | 1.30 | 7.6 | 4.3 | 7.4 | 44.2 | 37 | 16 | 16 | 6 | 21 | 36 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.64 |