| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 21 | 21 | 10 | 6 | 3.00 | .289 | 1.18 | 7.1 | 3.6 | 7.9 | 159.0 | 125 | 54 | 53 | 12 | 63 | 140 | 6 | 0 | 0 | 2 | 15 | 6 | 3 | 3.52 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 20 | 20 | 9 | 7 | 3.63 | .283 | 1.19 | 8.7 | 2.0 | 8.2 | 129.0 | 125 | 61 | 52 | 13 | 28 | 118 | 0 | 0 | 0 | 0 | 14 | 0 | 4 | 3.13 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 20 | 20 | 5 | 12 | 6.19 | .361 | 1.67 | 10.7 | 4.4 | 4.5 | 113.1 | 134 | 92 | 78 | 15 | 55 | 57 | 1 | 0 | 0 | 0 | 7 | 3 | 1 | 5.26 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 19 | 19 | 6 | 9 | 5.99 | .374 | 1.77 | 11.4 | 4.6 | 4.7 | 118.2 | 150 | 88 | 79 | 10 | 60 | 61 | 2 | 0 | 0 | 1 | 7 | 3 | 2 | 4.67 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 19 | 19 | 2 | 6 | 5.24 | .312 | 1.33 | 9.1 | 3.0 | 9.2 | 87.2 | 88 | 52 | 51 | 12 | 29 | 89 | 0 | 0 | 0 | 0 | 3 | 2 | 3 | 3.82 |
| RP | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 52 | 0 | 10 | 0 | 2.27 | .270 | 1.08 | 7.7 | 2.0 | 9.1 | 71.1 | 61 | 23 | 18 | 8 | 16 | 72 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 3.20 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 52 | 0 | 3 | 2 | 2.64 | .265 | 1.07 | 7.2 | 2.5 | 8.0 | 64.2 | 51 | 24 | 19 | 6 | 18 | 57 | 0 | 9 | 1 | 0 | 0 | 1 | 3 | 3.33 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 25 | 0 | 2 | 2 | 3.98 | .258 | 1.04 | 4.4 | 5.2 | 8.7 | 31.2 | 15 | 14 | 14 | 5 | 18 | 30 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 4.90 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 50 | 11 | 0 | 0 | 1 | 6.20 | .330 | 1.48 | 10.4 | 3.2 | 6.8 | 20.1 | 23 | 17 | 14 | 4 | 7 | 15 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5.15 |