| SP | deGrom, J.deGrom, Jacob $$ >> | 33 | 2021 | R | 100 | 21 | 21 | 6 | 7 | 4.14 | .290 | 1.21 | 8.3 | 2.6 | 9.5 | 124.0 | 114 | 59 | 57 | 16 | 36 | 131 | 0 | 0 | 0 | 0 | 13 | 2 | 0 | 3.48 |
| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 20 | 20 | 12 | 5 | 2.90 | .286 | 1.19 | 7.3 | 3.5 | 8.7 | 145.2 | 117 | 54 | 47 | 10 | 56 | 140 | 2 | 0 | 0 | 1 | 15 | 2 | 3 | 3.17 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 20 | 20 | 4 | 8 | 5.49 | .322 | 1.41 | 9.4 | 3.4 | 5.5 | 101.2 | 105 | 64 | 62 | 13 | 38 | 62 | 0 | 0 | 0 | 0 | 4 | 2 | 4 | 4.63 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 20 | 20 | 7 | 4 | 4.35 | .284 | 1.17 | 8.5 | 2.0 | 3.9 | 134.1 | 127 | 65 | 65 | 14 | 30 | 58 | 2 | 0 | 0 | 1 | 9 | 3 | 0 | 4.23 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 49 | 0 | 4 | 7 | 3.91 | .300 | 1.25 | 8.2 | 3.1 | 9.3 | 53.0 | 48 | 28 | 23 | 7 | 18 | 55 | 0 | 25 | 8 | 0 | 0 | 2 | 1 | 3.77 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 57 | 0 | 4 | 2 | 2.93 | .292 | 1.21 | 7.7 | 3.2 | 10.0 | 61.1 | 52 | 20 | 20 | 1 | 22 | 68 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 2.16 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 40 | 0 | 4 | 1 | 2.68 | .316 | 1.38 | 7.5 | 5.0 | 9.6 | 47.0 | 39 | 16 | 14 | 2 | 26 | 50 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.09 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 27 | 0 | 1 | 4 | 4.15 | .345 | 1.50 | 9.7 | 3.8 | 10.7 | 26.0 | 28 | 15 | 12 | 4 | 11 | 31 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 4.12 |
| SP | Coombs, J.Coombs, Jack >> | 28 | 1910 | R | 44 | 20 | 0 | 6 | 0 | 4.24 | .313 | 1.34 | 8.4 | 3.7 | 5.3 | 63.2 | 59 | 30 | 30 | 5 | 26 | 37 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.19 |