| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 24 | 24 | 6 | 11 | 4.88 | .322 | 1.39 | 8.9 | 3.6 | 9.2 | 151.1 | 150 | 87 | 82 | 18 | 61 | 155 | 1 | 0 | 0 | 0 | 12 | 5 | 1 | 3.81 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 23 | 23 | 5 | 13 | 5.68 | .342 | 1.53 | 9.4 | 4.4 | 8.5 | 123.2 | 129 | 83 | 78 | 19 | 60 | 116 | 0 | 0 | 0 | 0 | 11 | 4 | 2 | 4.68 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 23 | 23 | 7 | 7 | 4.78 | .313 | 1.32 | 9.3 | 2.6 | 5.3 | 150.2 | 155 | 80 | 80 | 15 | 44 | 89 | 1 | 0 | 0 | 1 | 10 | 7 | 1 | 4.13 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 22 | 22 | 7 | 12 | 4.63 | .332 | 1.48 | 10.0 | 3.3 | 4.1 | 159.1 | 177 | 87 | 82 | 22 | 59 | 73 | 7 | 0 | 0 | 0 | 11 | 2 | 2 | 5.03 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 77 | 0 | 3 | 4 | 4.75 | .266 | 1.09 | 7.5 | 2.4 | 8.1 | 60.2 | 50 | 35 | 32 | 8 | 16 | 54 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 3.73 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 53 | 0 | 5 | 4 | 4.41 | .343 | 1.55 | 10.3 | 3.7 | 8.7 | 63.1 | 72 | 32 | 31 | 8 | 26 | 61 | 0 | 8 | 5 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 49 | 0 | 2 | 4 | 4.97 | .318 | 1.40 | 6.5 | 6.3 | 9.4 | 50.2 | 36 | 31 | 28 | 7 | 35 | 52 | 0 | 5 | 1 | 0 | 0 | 0 | 3 | 4.84 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 36 | 0 | 0 | 1 | 3.86 | .291 | 1.23 | 7.5 | 3.6 | 10.5 | 37.1 | 31 | 19 | 16 | 6 | 15 | 43 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 4.00 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 63 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 20 | 0 | 2 | 1 | 4.26 | .349 | 1.61 | 10.5 | 4.4 | 5.5 | 31.2 | 36 | 18 | 15 | 4 | 15 | 19 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.90 |