| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 19 | 19 | 8 | 8 | 3.96 | .315 | 1.37 | 9.4 | 3.0 | 9.2 | 127.1 | 133 | 62 | 56 | 10 | 42 | 130 | 6 | 0 | 0 | 0 | 12 | 1 | 1 | 2.99 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 18 | 18 | 6 | 8 | 4.29 | .306 | 1.31 | 8.0 | 3.9 | 8.4 | 100.2 | 89 | 54 | 48 | 14 | 43 | 93 | 0 | 0 | 0 | 0 | 9 | 1 | 0 | 4.28 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 18 | 18 | 10 | 6 | 3.47 | .287 | 1.19 | 8.9 | 1.8 | 5.0 | 127.0 | 126 | 56 | 49 | 15 | 25 | 70 | 3 | 0 | 0 | 0 | 13 | 2 | 3 | 4.07 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 17 | 17 | 7 | 5 | 4.86 | .331 | 1.46 | 9.8 | 3.4 | 4.4 | 109.1 | 119 | 66 | 59 | 12 | 41 | 53 | 3 | 0 | 0 | 0 | 8 | 2 | 3 | 4.64 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 41 | 18 | 17 | 5 | 7 | 4.79 | .325 | 1.42 | 9.2 | 3.7 | 10.6 | 103.1 | 105 | 56 | 55 | 16 | 42 | 121 | 2 | 0 | 0 | 1 | 8 | 2 | 7 | 3.95 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 57 | 0 | 3 | 1 | 1.82 | .315 | 1.37 | 6.9 | 5.5 | 8.5 | 59.1 | 45 | 13 | 12 | 1 | 36 | 56 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 3.20 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 42 | 0 | 2 | 2 | 3.38 | .297 | 1.27 | 8.6 | 3.0 | 6.2 | 42.2 | 40 | 18 | 16 | 2 | 14 | 29 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.24 |