| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 97 | 29 | 29 | 15 | 7 | 3.87 | .298 | 1.25 | 8.7 | 2.6 | 9.7 | 160.2 | 154 | 72 | 69 | 24 | 47 | 172 | 3 | 0 | 0 | 2 | 12 | 4 | 4 | 3.76 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 28 | 28 | 12 | 8 | 4.62 | .311 | 1.32 | 9.4 | 2.5 | 9.1 | 150.0 | 157 | 81 | 77 | 21 | 41 | 152 | 1 | 0 | 0 | 0 | 10 | 5 | 9 | 3.71 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 27 | 27 | 10 | 5 | 4.42 | .326 | 1.41 | 9.8 | 3.0 | 8.4 | 146.2 | 159 | 80 | 72 | 20 | 48 | 137 | 1 | 0 | 0 | 0 | 11 | 6 | 3 | 4.01 |
| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 72 | 27 | 27 | 12 | 8 | 4.98 | .312 | 1.33 | 8.8 | 3.2 | 6.2 | 150.0 | 146 | 86 | 83 | 26 | 53 | 103 | 1 | 0 | 0 | 0 | 11 | 5 | 6 | 5.04 |
| SU | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 94 | 81 | 0 | 8 | 2 | 2.66 | .281 | 1.15 | 6.6 | 3.8 | 10.1 | 91.1 | 67 | 33 | 27 | 10 | 38 | 102 | 0 | 5 | 4 | 0 | 0 | 2 | 2 | 3.51 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 82 | 0 | 5 | 8 | 2.99 | .259 | 1.04 | 8.1 | 1.3 | 8.1 | 96.1 | 86 | 35 | 32 | 9 | 14 | 86 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 2.90 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 71 | 88 | 0 | 5 | 2 | 3.75 | .305 | 1.28 | 9.6 | 1.9 | 9.5 | 103.1 | 110 | 45 | 43 | 18 | 22 | 109 | 0 | 5 | 1 | 0 | 0 | 4 | 0 | 3.91 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 83 | 0 | 3 | 4 | 3.52 | .303 | 1.29 | 6.8 | 4.9 | 7.8 | 84.1 | 63 | 37 | 33 | 9 | 46 | 73 | 0 | 10 | 2 | 0 | 0 | 1 | 1 | 4.33 |
| RP | Sambito, J.Sambito, Joe >> | 28 | 1980 | L | 32 | 88 | 0 | 3 | 3 | 4.97 | .328 | 1.40 | 9.3 | 3.3 | 6.8 | 92.1 | 95 | 57 | 51 | 16 | 34 | 70 | 0 | 7 | 2 | 0 | 0 | 6 | 1 | 5.04 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 61 | 29 | 0 | 1 | 1 | 4.32 | .279 | 1.12 | 7.6 | 2.5 | 9.0 | 25.0 | 21 | 12 | 12 | 5 | 7 | 25 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.56 |