| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 29 | 29 | 14 | 7 | 3.52 | .281 | 1.15 | 8.6 | 1.8 | 10.8 | 176.2 | 168 | 72 | 69 | 30 | 35 | 212 | 0 | 0 | 0 | 0 | 20 | 4 | 0 | 3.47 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 28 | 28 | 8 | 12 | 5.39 | .346 | 1.53 | 10.3 | 3.5 | 9.6 | 155.1 | 178 | 103 | 93 | 31 | 60 | 165 | 0 | 0 | 0 | 0 | 11 | 9 | 3 | 4.81 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 27 | 27 | 15 | 5 | 4.06 | .313 | 1.33 | 9.1 | 2.9 | 6.6 | 177.1 | 179 | 82 | 80 | 30 | 57 | 130 | 5 | 0 | 0 | 0 | 17 | 6 | 0 | 4.80 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 72 | 26 | 25 | 8 | 10 | 4.79 | .327 | 1.43 | 9.1 | 3.9 | 5.9 | 133.1 | 134 | 78 | 71 | 18 | 57 | 87 | 2 | 0 | 0 | 1 | 14 | 3 | 2 | 4.80 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 81 | 0 | 4 | 1 | 4.15 | .316 | 1.36 | 7.2 | 5.1 | 8.6 | 69.1 | 55 | 33 | 32 | 11 | 39 | 66 | 0 | 8 | 0 | 0 | 0 | 2 | 0 | 4.94 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 68 | 0 | 3 | 1 | 4.33 | .299 | 1.27 | 7.4 | 4.1 | 11.5 | 68.2 | 56 | 33 | 33 | 14 | 31 | 87 | 0 | 7 | 5 | 0 | 0 | 1 | 3 | 4.53 |
| RP | Hoffman, T.Hoffman, Trevor # $$ >> | 31 | 1998 | R | 72 | 48 | 0 | 3 | 2 | 4.70 | .326 | 1.43 | 9.0 | 4.1 | 9.3 | 53.2 | 53 | 30 | 28 | 4 | 24 | 55 | 0 | 6 | 1 | 0 | 0 | 1 | 4 | 3.32 |
| RP | Niedenfuer, T.Niedenfuer, Tom $ >> | 24 | 1983 | R | 58 | 42 | 0 | 2 | 1 | 3.19 | .301 | 1.27 | 6.4 | 5.1 | 6.0 | 48.0 | 34 | 18 | 17 | 6 | 27 | 32 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5.04 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 61 | 0 | 2 | 6 | 3.42 | .275 | 1.11 | 8.0 | 2.1 | 9.3 | 81.2 | 72 | 31 | 31 | 12 | 19 | 84 | 0 | 13 | 5 | 0 | 0 | 2 | 1 | 3.63 |