| SP | Richard, J.Richard, J.R. $ >> | 30 | 1980 | R | 93 | 29 | 29 | 8 | 12 | 4.88 | .327 | 1.45 | 8.6 | 4.4 | 9.3 | 166.0 | 159 | 93 | 90 | 17 | 81 | 171 | 0 | 0 | 0 | 0 | 15 | 2 | 2 | 3.77 |
| SP | Johnson, R.Johnson, Randy $ >> | 41 | 2004 | L | 90 | 29 | 29 | 11 | 13 | 4.21 | .316 | 1.35 | 9.0 | 3.2 | 9.4 | 183.2 | 183 | 91 | 86 | 24 | 65 | 191 | 3 | 0 | 0 | 1 | 15 | 6 | 3 | 3.78 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 83 | 28 | 28 | 16 | 5 | 3.37 | .324 | 1.41 | 8.5 | 4.3 | 9.7 | 165.2 | 156 | 64 | 62 | 14 | 78 | 177 | 0 | 0 | 0 | 0 | 21 | 4 | 4 | 3.45 |
| SP | Fernandez, S.Fernandez, Sid † >> | 23 | 1985 | L | 53 | 26 | 26 | 13 | 6 | 3.07 | .303 | 1.28 | 7.0 | 4.5 | 9.1 | 176.0 | 137 | 63 | 60 | 14 | 88 | 177 | 2 | 0 | 0 | 1 | 18 | 5 | 4 | 3.61 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 80 | 0 | 8 | 4 | 3.69 | .309 | 1.33 | 7.9 | 4.1 | 9.1 | 102.1 | 89 | 49 | 42 | 9 | 47 | 103 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 3.54 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 68 | 0 | 4 | 1 | 4.03 | .309 | 1.32 | 9.4 | 2.6 | 9.4 | 73.2 | 76 | 34 | 33 | 6 | 21 | 76 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 2.93 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 55 | 0 | 6 | 1 | 3.30 | .292 | 1.21 | 7.2 | 3.7 | 11.5 | 71.0 | 57 | 26 | 26 | 9 | 29 | 91 | 0 | 4 | 3 | 0 | 0 | 2 | 0 | 3.39 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 76 | 40 | 0 | 3 | 2 | 7.93 | .377 | 1.71 | 11.3 | 4.3 | 4.8 | 36.1 | 45 | 32 | 32 | 10 | 17 | 19 | 0 | 2 | 1 | 0 | 0 | 4 | 0 | 7.31 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 33 | 0 | 2 | 0 | 4.15 | .293 | 1.24 | 6.4 | 5.0 | 10.1 | 34.2 | 24 | 16 | 16 | 6 | 19 | 38 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.74 |