| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 9 | 9 | 7 | 1 | 2.03 | .268 | 1.08 | 7.5 | 2.2 | 7.1 | 62.0 | 52 | 14 | 14 | 3 | 15 | 49 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 2.82 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 9 | 9 | 2 | 1 | 2.94 | .310 | 1.35 | 7.6 | 4.5 | 7.3 | 52.0 | 44 | 18 | 17 | 5 | 26 | 42 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 4.13 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 8 | 8 | 5 | 3 | 4.41 | .314 | 1.35 | 8.3 | 3.9 | 6.4 | 51.0 | 47 | 25 | 25 | 7 | 22 | 36 | 1 | 0 | 0 | 1 | 5 | 1 | 0 | 4.73 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 8 | 8 | 5 | 0 | 1.82 | .231 | 0.89 | 6.3 | 1.7 | 5.8 | 64.1 | 45 | 14 | 13 | 4 | 12 | 41 | 3 | 0 | 0 | 2 | 7 | 1 | 1 | 3.14 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 24 | 0 | 1 | 2 | 1.95 | .236 | 0.93 | 4.8 | 3.7 | 8.7 | 32.1 | 17 | 8 | 7 | 2 | 13 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.09 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 17 | 0 | 0 | 1 | 4.34 | .263 | 1.07 | 7.5 | 2.5 | 10.5 | 18.2 | 15 | 9 | 9 | 3 | 5 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3.67 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 14 | 0 | 0 | 1 | 5.29 | .320 | 1.35 | 7.4 | 4.8 | 10.6 | 17.0 | 14 | 14 | 10 | 6 | 9 | 20 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 7.00 |
| CL | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 20 | 0 | 2 | 3 | 2.63 | .234 | 0.92 | 4.9 | 3.4 | 4.9 | 24.0 | 13 | 7 | 7 | 0 | 9 | 13 | 0 | 10 | 2 | 0 | 0 | 0 | 0 | 3.04 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 14 | 0 | 1 | 1 | 0.83 | .261 | 1.02 | 5.6 | 3.9 | 13.3 | 21.2 | 13 | 3 | 2 | 0 | 9 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1.48 |