| SP | Richard, J.Richard, J.R. † >> | 30 | 1980 | R | 90 | 31 | 31 | 17 | 5 | 2.56 | .287 | 1.20 | 6.6 | 4.2 | 7.1 | 196.2 | 144 | 62 | 56 | 8 | 92 | 154 | 0 | 0 | 0 | 0 | 21 | 2 | 3 | 3.40 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 10 | 17 | 4.35 | .295 | 1.24 | 8.7 | 2.5 | 7.7 | 192.1 | 185 | 96 | 93 | 25 | 53 | 165 | 0 | 0 | 0 | 0 | 19 | 4 | 9 | 3.86 |
| SP | Johnson, R.Johnson, Randy † >> | 41 | 2004 | L | 84 | 29 | 29 | 17 | 6 | 3.49 | .291 | 1.22 | 8.2 | 2.7 | 8.4 | 209.0 | 191 | 85 | 81 | 19 | 63 | 194 | 5 | 0 | 0 | 1 | 19 | 3 | 0 | 3.27 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 85 | 87 | 0 | 7 | 5 | 2.70 | .255 | 1.01 | 7.4 | 1.8 | 8.1 | 126.2 | 103 | 43 | 38 | 12 | 25 | 113 | 0 | 8 | 2 | 0 | 0 | 2 | 1 | 3.09 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 78 | 0 | 7 | 2 | 2.83 | .276 | 1.12 | 5.3 | 4.8 | 7.1 | 105.0 | 62 | 36 | 33 | 8 | 56 | 83 | 0 | 9 | 2 | 0 | 0 | 2 | 1 | 4.07 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 63 | 0 | 4 | 2 | 3.41 | .323 | 1.42 | 7.0 | 5.8 | 8.4 | 71.1 | 55 | 28 | 27 | 5 | 46 | 66 | 0 | 15 | 4 | 0 | 0 | 1 | 1 | 4.04 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 38 | 0 | 2 | 2 | 3.46 | .290 | 1.20 | 6.1 | 4.8 | 8.6 | 41.2 | 28 | 17 | 16 | 5 | 22 | 39 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 4.37 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 31 | 0 | 2 | 4 | 3.86 | .325 | 1.42 | 7.3 | 5.6 | 6.6 | 37.1 | 30 | 16 | 16 | 3 | 23 | 27 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 4.54 |