| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 35 | 35 | 13 | 14 | 4.20 | .291 | 1.19 | 8.0 | 2.7 | 8.4 | 253.0 | 226 | 127 | 118 | 38 | 76 | 236 | 10 | 0 | 0 | 1 | 17 | 10 | 10 | 4.11 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 33 | 33 | 11 | 9 | 4.77 | .328 | 1.46 | 10.5 | 2.7 | 4.5 | 169.2 | 197 | 95 | 90 | 21 | 51 | 84 | 0 | 0 | 0 | 0 | 11 | 1 | 3 | 4.54 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 32 | 32 | 13 | 7 | 4.45 | .310 | 1.33 | 8.1 | 3.8 | 8.0 | 190.0 | 172 | 101 | 94 | 26 | 81 | 169 | 0 | 0 | 0 | 0 | 16 | 3 | 7 | 4.33 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 79 | 0 | 4 | 1 | 3.92 | .322 | 1.41 | 8.3 | 4.4 | 8.3 | 108.0 | 99 | 49 | 47 | 8 | 53 | 100 | 0 | 5 | 3 | 0 | 0 | 2 | 12 | 3.64 |
| RP | Zimmerman, J.Zimmerman, Jeff † >> | 27 | 1999 | R | 70 | 72 | 0 | 10 | 7 | 5.16 | .333 | 1.49 | 8.7 | 4.7 | 4.4 | 96.0 | 93 | 59 | 55 | 12 | 50 | 47 | 0 | 9 | 3 | 0 | 0 | 1 | 3 | 5.24 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 56 | 0 | 4 | 3 | 3.65 | .320 | 1.38 | 8.2 | 4.4 | 9.4 | 66.2 | 60 | 28 | 27 | 5 | 32 | 69 | 0 | 6 | 5 | 0 | 0 | 2 | 3 | 3.44 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 48 | 0 | 3 | 2 | 4.39 | .310 | 1.31 | 9.3 | 2.5 | 7.5 | 53.1 | 55 | 30 | 26 | 5 | 15 | 44 | 0 | 6 | 2 | 0 | 0 | 2 | 2 | 3.53 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 27 | 0 | 1 | 2 | 5.02 | .276 | 1.12 | 8.8 | 1.5 | 9.0 | 37.2 | 36 | 21 | 21 | 7 | 6 | 37 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.03 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 31 | 0 | 1 | 1 | 4.34 | .364 | 1.71 | 7.5 | 8.0 | 7.8 | 37.1 | 31 | 18 | 18 | 5 | 33 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 5.70 |