| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 7 | 7 | 3 | 4 | 4.26 | .261 | 1.06 | 7.2 | 2.5 | 8.6 | 44.1 | 35 | 22 | 21 | 8 | 12 | 42 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 4.27 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 6 | 6 | 0 | 3 | 6.12 | .345 | 1.58 | 11.3 | 3.1 | 6.5 | 32.1 | 40 | 24 | 22 | 3 | 11 | 23 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 3.81 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 6 | 6 | 0 | 5 | 8.16 | .403 | 1.99 | 12.5 | 5.8 | 9.3 | 28.2 | 39 | 28 | 26 | 5 | 18 | 29 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 5.29 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 7 | 6 | 1 | 3 | 6.25 | .331 | 1.49 | 11.0 | 2.5 | 5.6 | 40.1 | 49 | 28 | 28 | 5 | 11 | 25 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 4.20 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 14 | 0 | 1 | 0 | 2.11 | .238 | 0.94 | 4.7 | 3.9 | 6.9 | 21.1 | 11 | 5 | 5 | 1 | 9 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 10 | 0 | 0 | 2 | 6.39 | .309 | 1.34 | 9.0 | 3.8 | 7.5 | 12.2 | 12 | 9 | 9 | 2 | 5 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.75 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 10 | 0 | 3 | 1 | 3.46 | .235 | 0.85 | 5.5 | 2.1 | 5.5 | 13.0 | 8 | 5 | 5 | 2 | 3 | 8 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 4.69 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 7 | 0 | 0 | 0 | 2.79 | .237 | 0.93 | 6.0 | 3.0 | 9.0 | 9.2 | 6 | 3 | 3 | 1 | 3 | 9 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.44 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 2 | 0 | 0 | 0 | 13.50 | .444 | 2.40 | 24.0 | 0.0 | 9.0 | 3.1 | 8 | 5 | 5 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.00 |