| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 7 | 7 | 4 | 0 | 2.26 | .241 | 0.95 | 7.2 | 1.5 | 8.7 | 55.2 | 44 | 14 | 14 | 2 | 9 | 53 | 1 | 0 | 0 | 0 | 6 | 0 | 1 | 2.04 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 7 | 7 | 7 | 0 | 2.96 | .291 | 1.23 | 6.2 | 5.1 | 8.3 | 48.2 | 33 | 16 | 16 | 4 | 27 | 44 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 3.94 |
| SP | Caldwell, R.Caldwell, Ray # >> | 26 | 1914 | R | 64 | 6 | 6 | 2 | 3 | 5.03 | .363 | 1.68 | 9.5 | 5.6 | 5.3 | 34.0 | 36 | 19 | 19 | 4 | 21 | 20 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 5.29 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 19 | 0 | 2 | 1 | 2.35 | .233 | 0.87 | 5.1 | 2.7 | 8.6 | 23.0 | 13 | 6 | 6 | 4 | 7 | 22 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 4.39 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 14 | 0 | 2 | 0 | 2.29 | .280 | 1.17 | 7.1 | 3.8 | 8.1 | 19.2 | 15 | 5 | 5 | 2 | 8 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.84 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 11 | 0 | 0 | 0 | 1.98 | .241 | 0.95 | 2.8 | 6.2 | 11.8 | 13.2 | 4 | 3 | 3 | 1 | 9 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.46 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 6 | 0 | 0 | 0 | 4.76 | .370 | 1.76 | 10.8 | 7.2 | 14.4 | 5.2 | 6 | 3 | 3 | 0 | 4 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.20 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 7 | 0 | 0 | 1 | 7.36 | .389 | 1.77 | 11.6 | 5.1 | 9.0 | 7.1 | 9 | 6 | 6 | 1 | 4 | 7 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.00 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 0 | 0 | 0 | 13.50 | .600 | 4.50 | 36.0 | 18.0 | 9.0 | 1.1 | 4 | 3 | 2 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.00 |