| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 31 | 31 | 16 | 4 | 2.10 | .255 | 1.02 | 6.9 | 2.3 | 8.4 | 214.2 | 165 | 54 | 50 | 11 | 55 | 199 | 1 | 0 | 0 | 1 | 26 | 1 | 0 | 2.59 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 82 | 30 | 30 | 15 | 9 | 3.21 | .269 | 1.10 | 8.0 | 1.9 | 4.2 | 213.1 | 190 | 86 | 76 | 13 | 45 | 100 | 4 | 0 | 0 | 1 | 20 | 0 | 1 | 3.49 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 30 | 30 | 20 | 6 | 2.17 | .266 | 1.06 | 6.2 | 3.3 | 8.1 | 212.0 | 146 | 55 | 51 | 13 | 78 | 190 | 3 | 0 | 0 | 0 | 24 | 6 | 4 | 3.19 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 68 | 0 | 9 | 4 | 2.54 | .262 | 1.03 | 6.1 | 3.1 | 9.0 | 78.0 | 53 | 25 | 22 | 2 | 27 | 78 | 0 | 1 | 1 | 0 | 0 | 3 | 5 | 2.49 |
| SU | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 51 | 0 | 1 | 3 | 3.42 | .294 | 1.23 | 7.4 | 3.8 | 8.3 | 55.1 | 45 | 21 | 21 | 4 | 23 | 51 | 0 | 8 | 10 | 0 | 0 | 1 | 2 | 3.40 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 31 | 0 | 2 | 3 | 2.76 | .315 | 1.35 | 9.6 | 2.8 | 7.9 | 32.2 | 34 | 13 | 10 | 1 | 10 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 2.69 |
| CL | Rhodes, A.Rhodes, Arthur † >> | 32 | 2001 | L | 64 | 59 | 0 | 2 | 4 | 2.76 | .246 | 0.95 | 6.5 | 2.1 | 9.3 | 65.1 | 47 | 20 | 20 | 5 | 15 | 67 | 0 | 39 | 3 | 0 | 0 | 2 | 2 | 2.72 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 22 | 0 | 2 | 0 | 4.57 | .253 | 1.02 | 6.0 | 3.4 | 6.9 | 21.2 | 14 | 11 | 11 | 3 | 8 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.48 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 1 | 0 | 0 | 4.05 | .259 | 1.05 | 7.5 | 3.0 | 4.5 | 6.2 | 5 | 3 | 3 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.00 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |