| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 10 | 10 | 0 | 6 | 6.71 | .350 | 1.58 | 9.0 | 5.2 | 8.5 | 55.0 | 55 | 51 | 41 | 10 | 32 | 52 | 0 | 0 | 0 | 0 | 2 | 2 | 4 | 5.33 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 9 | 9 | 2 | 3 | 5.49 | .352 | 1.61 | 11.0 | 3.5 | 4.7 | 59.0 | 72 | 41 | 36 | 6 | 23 | 31 | 2 | 0 | 0 | 0 | 4 | 1 | 3 | 4.49 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 9 | 9 | 0 | 6 | 5.46 | .357 | 1.61 | 11.4 | 3.3 | 8.2 | 57.2 | 72 | 39 | 35 | 8 | 21 | 52 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 4.26 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 9 | 9 | 4 | 3 | 4.18 | .339 | 1.54 | 10.1 | 3.9 | 6.2 | 60.1 | 67 | 42 | 28 | 9 | 26 | 41 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 4.88 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 26 | 0 | 2 | 2 | 5.28 | .343 | 1.50 | 9.0 | 4.8 | 10.5 | 30.2 | 30 | 21 | 18 | 6 | 16 | 35 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 5.07 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 21 | 0 | 0 | 2 | 5.92 | .330 | 1.48 | 9.4 | 4.1 | 10.9 | 24.1 | 25 | 16 | 16 | 2 | 11 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.04 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 20 | 0 | 3 | 2 | 4.50 | .305 | 1.27 | 7.8 | 3.7 | 8.6 | 22.0 | 19 | 11 | 11 | 2 | 9 | 21 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.64 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 2 | 0 | 1 | 1 | 7.36 | .267 | 1.09 | 6.0 | 6.0 | 9.0 | 3.2 | 2 | 3 | 3 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |