| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 24 | 24 | 9 | 8 | 3.89 | .309 | 1.32 | 9.2 | 2.7 | 10.3 | 143.1 | 146 | 64 | 62 | 13 | 43 | 163 | 0 | 0 | 0 | 0 | 16 | 3 | 2 | 2.87 |
| SP | Peralta, F.Peralta, Freddy $ >> | 29 | 2025 | R | 89 | 24 | 24 | 10 | 7 | 3.50 | .261 | 1.04 | 6.9 | 2.5 | 10.1 | 139.0 | 106 | 60 | 54 | 12 | 39 | 156 | 0 | 0 | 0 | 0 | 13 | 2 | 3 | 2.76 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 64 | 22 | 22 | 5 | 6 | 5.22 | .330 | 1.45 | 9.1 | 4.0 | 7.9 | 88.0 | 89 | 54 | 51 | 11 | 39 | 77 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 4.27 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 93 | 65 | 0 | 7 | 3 | 2.32 | .254 | 0.98 | 6.5 | 2.3 | 8.4 | 97.0 | 70 | 27 | 25 | 8 | 25 | 90 | 0 | 3 | 3 | 0 | 0 | 4 | 0 | 3.11 |
| RP | Cleavinger, G.Cleavinger, Garrett † >> | 31 | 2025 | L | 93 | 62 | 0 | 7 | 0 | 1.58 | .237 | 0.92 | 4.0 | 4.3 | 10.2 | 85.2 | 38 | 17 | 15 | 3 | 41 | 96 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 2.68 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 88 | 64 | 0 | 5 | 10 | 3.64 | .262 | 1.02 | 6.1 | 3.1 | 7.3 | 81.2 | 55 | 33 | 33 | 8 | 28 | 66 | 0 | 12 | 4 | 0 | 0 | 4 | 3 | 3.84 |
| RP | Miller, S.Miller, Shelby $ >> | 34 | 2025 | R | 84 | 43 | 0 | 1 | 1 | 2.06 | .261 | 1.04 | 6.8 | 2.7 | 8.8 | 56.2 | 42 | 13 | 13 | 6 | 17 | 55 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.39 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 79 | 42 | 0 | 2 | 4 | 3.09 | .282 | 1.14 | 7.4 | 2.9 | 9.2 | 46.2 | 38 | 16 | 16 | 4 | 15 | 47 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.20 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 72 | 39 | 0 | 3 | 1 | 1.96 | .236 | 0.87 | 4.9 | 2.9 | 10.5 | 55.0 | 30 | 12 | 12 | 6 | 18 | 64 | 0 | 3 | 0 | 0 | 0 | 3 | 1 | 3.24 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 71 | 41 | 0 | 9 | 2 | 4.78 | .328 | 1.44 | 9.0 | 4.2 | 10.7 | 52.2 | 52 | 28 | 28 | 10 | 24 | 62 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.56 |