| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 15 | 15 | 8 | 5 | 4.24 | .311 | 1.29 | 9.8 | 1.8 | 8.7 | 87.0 | 95 | 45 | 41 | 10 | 17 | 84 | 0 | 0 | 0 | 0 | 10 | 6 | 2 | 3.36 |
| SP | Gilbert, L.Gilbert, Logan >> | 28 | 2025 | R | 91 | 15 | 15 | 3 | 6 | 6.23 | .374 | 1.74 | 12.1 | 3.7 | 10.6 | 73.2 | 98 | 51 | 51 | 15 | 30 | 86 | 0 | 0 | 0 | 0 | 3 | 4 | 4 | 4.71 |
| SP | Taillon, J.Taillon, Jameson >> | 33 | 2025 | R | 77 | 15 | 15 | 1 | 8 | 5.44 | .349 | 1.58 | 11.5 | 2.9 | 7.5 | 82.2 | 105 | 50 | 50 | 18 | 26 | 68 | 0 | 0 | 0 | 0 | 6 | 2 | 2 | 5.22 |
| SP | Valdez, F.Valdez, Framber # >> | 31 | 2025 | L | 63 | 16 | 15 | 6 | 4 | 4.82 | .322 | 1.38 | 9.3 | 3.2 | 9.4 | 89.2 | 92 | 48 | 48 | 19 | 32 | 93 | 1 | 0 | 0 | 1 | 8 | 4 | 2 | 4.90 |
| CL | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 42 | 0 | 2 | 2 | 2.97 | .248 | 0.99 | 5.1 | 3.9 | 7.6 | 39.1 | 22 | 13 | 13 | 5 | 17 | 33 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.28 |
| RP | Rodríguez, R.Rodríguez, Randy >> | 25 | 2025 | R | 96 | 31 | 0 | 0 | 1 | 6.39 | .356 | 1.62 | 10.4 | 4.3 | 9.7 | 25.1 | 29 | 18 | 18 | 6 | 12 | 27 | 0 | 12 | 2 | 0 | 0 | 1 | 2 | 5.52 |
| RP | Finnegan, K.Finnegan, Kyle >> | 33 | 2025 | R | 66 | 38 | 0 | 1 | 2 | 3.52 | .258 | 1.04 | 6.6 | 3.0 | 8.7 | 30.2 | 22 | 12 | 12 | 3 | 10 | 29 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 3.37 |
| RP | Koenig, J.Koenig, Jared >> | 31 | 2025 | L | 58 | 17 | 0 | 0 | 2 | 3.14 | .218 | 0.84 | 5.1 | 2.6 | 10.9 | 14.1 | 8 | 6 | 5 | 2 | 4 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.29 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 36 | 0 | 1 | 0 | 5.23 | .345 | 1.55 | 9.6 | 4.4 | 9.0 | 31.0 | 33 | 18 | 18 | 6 | 15 | 31 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 5.06 |
| SP | Holmes, C.Holmes, Clay >> | 32 | 2025 | R | 41 | 3 | 0 | 0 | 0 | 5.91 | .407 | 2.06 | 14.4 | 5.4 | 10.8 | 10.2 | 16 | 7 | 7 | 0 | 6 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.40 |