| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 27 | 27 | 13 | 6 | 3.58 | .289 | 1.21 | 8.6 | 2.3 | 10.6 | 176.0 | 168 | 72 | 70 | 22 | 45 | 207 | 1 | 0 | 0 | 1 | 16 | 2 | 0 | 3.07 |
| SP | Sanchez, C.Sanchez, Cristopher † # >> | 28 | 2025 | L | 82 | 25 | 25 | 16 | 3 | 3.77 | .271 | 1.09 | 8.4 | 1.4 | 10.4 | 172.0 | 161 | 75 | 72 | 23 | 26 | 199 | 1 | 0 | 0 | 0 | 16 | 5 | 10 | 2.97 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 67 | 25 | 25 | 12 | 6 | 5.09 | .326 | 1.41 | 9.9 | 2.8 | 7.6 | 145.0 | 160 | 88 | 82 | 26 | 45 | 123 | 0 | 0 | 0 | 0 | 11 | 5 | 1 | 4.67 |
| RP | Hader, J.Hader, Josh † >> | 31 | 2025 | L | 100 | 74 | 0 | 8 | 4 | 2.99 | .275 | 1.10 | 6.7 | 3.3 | 12.3 | 105.1 | 78 | 35 | 35 | 11 | 38 | 143 | 0 | 8 | 6 | 0 | 0 | 4 | 0 | 2.84 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 91 | 74 | 0 | 8 | 6 | 3.86 | .320 | 1.36 | 9.2 | 3.1 | 10.7 | 93.1 | 95 | 43 | 40 | 10 | 32 | 111 | 0 | 8 | 1 | 0 | 0 | 5 | 1 | 3.20 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 75 | 0 | 1 | 7 | 5.49 | .329 | 1.43 | 8.7 | 4.3 | 10.4 | 80.1 | 77 | 49 | 49 | 14 | 38 | 92 | 0 | 9 | 2 | 0 | 0 | 3 | 2 | 4.51 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 77 | 56 | 0 | 4 | 1 | 2.67 | .299 | 1.23 | 6.6 | 4.5 | 11.1 | 64.0 | 47 | 19 | 19 | 6 | 32 | 79 | 0 | 7 | 2 | 0 | 0 | 3 | 1 | 3.39 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 71 | 50 | 0 | 3 | 4 | 5.14 | .351 | 1.63 | 9.0 | 5.6 | 10.8 | 56.0 | 56 | 32 | 32 | 9 | 35 | 67 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.57 |