| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 72 | 34 | 34 | 15 | 14 | 4.17 | .318 | 1.39 | 9.0 | 3.6 | 6.4 | 194.1 | 193 | 103 | 90 | 29 | 77 | 139 | 0 | 0 | 0 | 0 | 19 | 2 | 3 | 4.73 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 68 | 32 | 31 | 8 | 14 | 5.47 | .341 | 1.52 | 9.7 | 4.0 | 6.5 | 192.2 | 207 | 121 | 117 | 33 | 86 | 139 | 2 | 0 | 0 | 0 | 10 | 6 | 4 | 5.22 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 64 | 34 | 33 | 9 | 20 | 7.83 | .367 | 1.72 | 11.4 | 4.2 | 7.3 | 156.1 | 197 | 139 | 136 | 39 | 72 | 126 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 6.08 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 34 | 32 | 8 | 13 | 5.97 | .343 | 1.54 | 11.2 | 2.7 | 5.7 | 179.1 | 222 | 129 | 119 | 34 | 54 | 114 | 3 | 0 | 0 | 2 | 10 | 5 | 7 | 5.18 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 60 | 32 | 32 | 10 | 11 | 6.21 | .347 | 1.56 | 11.0 | 3.1 | 6.4 | 179.2 | 218 | 133 | 124 | 36 | 62 | 127 | 4 | 0 | 0 | 1 | 9 | 6 | 4 | 5.34 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 111 | 0 | 6 | 3 | 3.90 | .314 | 1.35 | 7.5 | 4.6 | 8.7 | 136.0 | 114 | 64 | 59 | 19 | 69 | 131 | 0 | 8 | 0 | 0 | 0 | 4 | 2 | 4.50 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 96 | 0 | 6 | 2 | 4.82 | .293 | 1.22 | 7.7 | 3.3 | 9.2 | 112.0 | 96 | 62 | 60 | 22 | 41 | 114 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 4.67 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 93 | 0 | 5 | 5 | 4.40 | .333 | 1.48 | 9.5 | 3.8 | 9.8 | 108.1 | 114 | 66 | 53 | 17 | 46 | 118 | 0 | 14 | 3 | 0 | 0 | 2 | 0 | 4.19 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 74 | 67 | 0 | 3 | 4 | 5.33 | .324 | 1.44 | 9.9 | 3.2 | 9.6 | 74.1 | 81 | 46 | 44 | 21 | 26 | 79 | 0 | 5 | 0 | 0 | 0 | 0 | 2 | 5.61 |