| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 31 | 31 | 9 | 13 | 4.28 | .308 | 1.31 | 8.3 | 3.5 | 8.1 | 200.0 | 184 | 104 | 95 | 25 | 78 | 179 | 2 | 0 | 0 | 0 | 19 | 5 | 5 | 4.08 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 30 | 30 | 17 | 11 | 3.76 | .272 | 1.09 | 7.7 | 2.1 | 5.1 | 220.1 | 189 | 99 | 92 | 27 | 51 | 125 | 14 | 0 | 0 | 4 | 16 | 7 | 4 | 4.25 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 29 | 29 | 10 | 10 | 4.09 | .283 | 1.15 | 7.4 | 2.9 | 4.0 | 209.0 | 173 | 96 | 95 | 29 | 67 | 94 | 9 | 0 | 0 | 0 | 17 | 7 | 2 | 4.97 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 29 | 29 | 13 | 14 | 4.91 | .327 | 1.42 | 9.1 | 3.7 | 4.9 | 203.2 | 206 | 114 | 111 | 26 | 83 | 110 | 13 | 0 | 0 | 1 | 13 | 8 | 2 | 4.93 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 64 | 0 | 8 | 1 | 2.74 | .279 | 1.15 | 6.0 | 4.3 | 8.3 | 82.0 | 55 | 26 | 25 | 10 | 39 | 76 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 4.20 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 35 | 0 | 3 | 3 | 4.10 | .248 | 0.96 | 6.3 | 2.4 | 8.3 | 37.1 | 26 | 18 | 17 | 6 | 10 | 34 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 4.16 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 12 | 0 | 0 | 1 | 4.40 | .403 | 1.95 | 5.8 | 12.2 | 9.0 | 14.1 | 9 | 7 | 7 | 2 | 19 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.14 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 19 | 0 | 5 | 3 | 4.53 | .290 | 1.16 | 7.1 | 3.3 | 4.4 | 97.1 | 77 | 52 | 49 | 14 | 36 | 47 | 0 | 0 | 0 | 0 | 0 | 6 | 5 | 5.21 |