| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 15 | 15 | 5 | 7 | 2.84 | .268 | 1.10 | 7.0 | 2.9 | 4.3 | 117.1 | 91 | 40 | 37 | 5 | 38 | 56 | 4 | 0 | 0 | 1 | 11 | 0 | 2 | 3.57 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 15 | 15 | 3 | 9 | 7.27 | .377 | 1.80 | 12.8 | 3.5 | 3.7 | 95.1 | 135 | 79 | 77 | 18 | 37 | 39 | 3 | 0 | 0 | 1 | 2 | 1 | 3 | 5.84 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 14 | 14 | 3 | 11 | 6.87 | .346 | 1.56 | 10.1 | 3.9 | 5.4 | 94.1 | 106 | 73 | 72 | 16 | 41 | 56 | 3 | 0 | 0 | 1 | 2 | 3 | 3 | 5.43 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 44 | 0 | 0 | 3 | 2.85 | .226 | 0.88 | 6.1 | 1.9 | 10.2 | 53.2 | 36 | 17 | 17 | 8 | 11 | 60 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.32 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 33 | 0 | 2 | 1 | 3.29 | .311 | 1.36 | 7.3 | 5.0 | 11.8 | 38.1 | 31 | 16 | 14 | 5 | 21 | 50 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 3.74 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 24 | 0 | 2 | 3 | 3.58 | .347 | 1.59 | 9.0 | 5.6 | 6.1 | 37.2 | 37 | 15 | 15 | 6 | 23 | 25 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 5.62 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 53 | 3 | 0 | 2 | 0 | 2.35 | .324 | 1.43 | 10.3 | 3.9 | 7.7 | 7.2 | 8 | 2 | 2 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.57 |