| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 7 | 2 | 3.84 | .265 | 1.06 | 7.7 | 1.9 | 11.5 | 91.1 | 78 | 40 | 39 | 14 | 19 | 116 | 1 | 0 | 0 | 0 | 10 | 2 | 0 | 3.14 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 16 | 15 | 7 | 5 | 4.01 | .300 | 1.26 | 9.5 | 1.9 | 8.7 | 94.1 | 99 | 42 | 42 | 10 | 20 | 91 | 1 | 0 | 0 | 0 | 9 | 2 | 1 | 3.15 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 1 | 8 | 7.49 | .378 | 1.77 | 11.6 | 4.4 | 7.5 | 67.1 | 86 | 61 | 56 | 14 | 33 | 56 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 5.70 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 14 | 14 | 1 | 7 | 6.48 | .370 | 1.75 | 10.7 | 5.2 | 5.2 | 73.2 | 87 | 54 | 53 | 16 | 42 | 42 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 6.47 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 43 | 0 | 0 | 6 | 4.23 | .291 | 1.21 | 8.4 | 2.7 | 10.2 | 44.2 | 41 | 23 | 21 | 7 | 13 | 50 | 0 | 14 | 3 | 0 | 0 | 1 | 0 | 3.75 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 45 | 0 | 2 | 4 | 5.33 | .311 | 1.30 | 8.0 | 3.8 | 8.0 | 52.1 | 46 | 31 | 31 | 11 | 22 | 46 | 0 | 1 | 5 | 0 | 0 | 3 | 0 | 5.42 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 47 | 0 | 4 | 1 | 4.44 | .303 | 1.28 | 9.7 | 2.0 | 7.6 | 50.2 | 54 | 25 | 25 | 8 | 11 | 42 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.12 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 39 | 0 | 3 | 2 | 3.33 | .293 | 1.22 | 6.8 | 4.2 | 9.3 | 54.0 | 41 | 20 | 20 | 8 | 25 | 56 | 0 | 1 | 3 | 0 | 0 | 1 | 3 | 4.30 |