| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 31 | 31 | 8 | 12 | 5.32 | .333 | 1.47 | 10.2 | 3.1 | 9.1 | 162.1 | 183 | 99 | 96 | 20 | 55 | 164 | 2 | 0 | 0 | 1 | 13 | 5 | 3 | 3.69 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 31 | 31 | 8 | 14 | 5.66 | .339 | 1.52 | 10.4 | 3.3 | 9.4 | 168.2 | 195 | 115 | 106 | 36 | 62 | 176 | 1 | 0 | 0 | 0 | 12 | 2 | 5 | 4.83 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 29 | 29 | 9 | 13 | 4.85 | .327 | 1.44 | 9.5 | 3.4 | 4.9 | 187.1 | 198 | 116 | 101 | 21 | 71 | 102 | 6 | 0 | 0 | 0 | 11 | 4 | 1 | 4.57 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 30 | 29 | 6 | 12 | 5.31 | .336 | 1.49 | 10.1 | 3.4 | 5.6 | 159.1 | 178 | 103 | 94 | 28 | 60 | 99 | 4 | 0 | 0 | 2 | 10 | 4 | 3 | 5.25 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 71 | 33 | 27 | 7 | 15 | 4.22 | .298 | 1.25 | 8.5 | 2.8 | 5.2 | 172.2 | 162 | 91 | 81 | 23 | 53 | 99 | 0 | 1 | 0 | 0 | 13 | 5 | 3 | 4.60 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 83 | 0 | 5 | 7 | 3.41 | .283 | 1.16 | 8.1 | 2.4 | 8.3 | 105.2 | 95 | 40 | 40 | 15 | 28 | 97 | 0 | 19 | 4 | 0 | 0 | 2 | 1 | 3.87 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 89 | 0 | 4 | 3 | 3.85 | .310 | 1.30 | 7.9 | 3.9 | 9.9 | 107.2 | 94 | 50 | 46 | 8 | 46 | 118 | 0 | 5 | 8 | 0 | 0 | 5 | 0 | 3.20 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 74 | 0 | 4 | 5 | 4.59 | .365 | 1.72 | 9.4 | 6.1 | 10.6 | 82.1 | 86 | 42 | 42 | 13 | 56 | 97 | 0 | 3 | 2 | 0 | 0 | 0 | 5 | 4.74 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 89 | 0 | 5 | 0 | 4.08 | .347 | 1.58 | 9.2 | 5.1 | 8.1 | 92.2 | 94 | 50 | 42 | 13 | 52 | 83 | 0 | 0 | 0 | 0 | 0 | 2 | 12 | 4.79 |