| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 15 | 15 | 5 | 8 | 4.78 | .293 | 1.23 | 8.5 | 2.7 | 8.2 | 105.1 | 99 | 56 | 56 | 11 | 31 | 96 | 3 | 0 | 0 | 0 | 6 | 1 | 0 | 3.45 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 15 | 15 | 4 | 7 | 5.14 | .326 | 1.45 | 10.1 | 3.0 | 7.8 | 96.1 | 108 | 60 | 55 | 17 | 32 | 83 | 1 | 0 | 0 | 0 | 9 | 0 | 3 | 4.57 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 15 | 15 | 8 | 6 | 4.80 | .326 | 1.43 | 9.5 | 3.5 | 6.4 | 95.2 | 100 | 52 | 51 | 13 | 37 | 68 | 2 | 0 | 0 | 0 | 8 | 2 | 4 | 4.58 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 14 | 14 | 6 | 7 | 4.04 | .300 | 1.27 | 8.9 | 2.5 | 4.8 | 98.0 | 97 | 49 | 44 | 6 | 27 | 52 | 7 | 0 | 0 | 1 | 8 | 2 | 2 | 3.62 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 24 | 0 | 2 | 1 | 5.09 | .330 | 1.43 | 9.0 | 3.9 | 6.3 | 23.0 | 23 | 14 | 13 | 5 | 10 | 16 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 5.87 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 11 | 0 | 1 | 1 | 5.87 | .303 | 1.24 | 10.2 | 1.2 | 10.8 | 15.1 | 17 | 10 | 10 | 3 | 2 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.80 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 7 | 0 | 0 | 0 | 18.69 | .500 | 3.00 | 22.5 | 6.8 | 4.5 | 4.1 | 10 | 9 | 9 | 3 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 14.00 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 9 | 0 | 0 | 0 | 0.00 | .258 | 0.91 | 6.4 | 2.6 | 11.6 | 7.2 | 5 | 0 | 0 | 0 | 2 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1.71 |