| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 60 | 39 | 39 | 17 | 14 | 4.68 | .326 | 1.44 | 8.5 | 4.4 | 7.1 | 250.0 | 237 | 130 | 130 | 26 | 123 | 197 | 6 | 0 | 0 | 1 | 21 | 2 | 11 | 4.28 |
| SP | Chacin, J.Chacin, Jhoulys # >> | 22 | 2010 | R | 46 | 36 | 36 | 2 | 5 | 6.30 | .335 | 1.50 | 9.4 | 4.2 | 9.1 | 135.2 | 141 | 96 | 95 | 19 | 63 | 136 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4.24 |
| SP | Thomson, J.Thomson, John >> | 28 | 2001 | R | 48 | 35 | 35 | 0 | 7 | 4.84 | .315 | 1.35 | 9.5 | 2.7 | 5.5 | 89.1 | 94 | 48 | 48 | 10 | 27 | 54 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 4.22 |
| SP | Marquez, G.Marquez, German >> | 23 | 2018 | R | 47 | 32 | 31 | 12 | 8 | 5.40 | .345 | 1.56 | 10.5 | 3.6 | 8.8 | 146.2 | 170 | 92 | 88 | 28 | 59 | 142 | 0 | 0 | 0 | 0 | 2 | 3 | 10 | 4.82 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 66 | 97 | 0 | 17 | 3 | 3.76 | .302 | 1.30 | 6.7 | 5.0 | 8.9 | 136.1 | 101 | 62 | 57 | 16 | 76 | 134 | 0 | 3 | 3 | 0 | 0 | 0 | 9 | 4.24 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 54 | 75 | 0 | 6 | 2 | 2.82 | .274 | 1.11 | 5.9 | 4.1 | 8.5 | 99.0 | 65 | 35 | 31 | 9 | 45 | 93 | 0 | 3 | 5 | 0 | 0 | 2 | 2 | 3.73 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 63 | 54 | 0 | 5 | 3 | 3.80 | .274 | 1.12 | 7.9 | 2.2 | 8.2 | 66.1 | 58 | 28 | 28 | 8 | 16 | 60 | 0 | 7 | 1 | 0 | 0 | 1 | 1 | 3.53 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 53 | 50 | 0 | 1 | 2 | 2.66 | .244 | 0.93 | 5.6 | 2.8 | 9.3 | 61.0 | 38 | 18 | 18 | 6 | 19 | 63 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 3.25 |
| RP | DeJean, M.DeJean, Mike # >> | 35 | 2005 | R | 42 | 48 | 0 | 4 | 2 | 6.03 | .324 | 1.44 | 9.4 | 3.6 | 5.4 | 62.2 | 65 | 42 | 42 | 4 | 25 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 3.85 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 30 | 2011 | L | 52 | 76 | 0 | 22 | 4 | 5.06 | .349 | 1.61 | 9.9 | 4.6 | 5.7 | 181.1 | 199 | 111 | 102 | 21 | 93 | 114 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 4.79 |