| SP | McNally, D.McNally, Dave † >> | 26 | 1968 | L | 92 | 31 | 31 | 15 | 13 | 2.89 | .270 | 1.08 | 6.9 | 2.9 | 5.2 | 261.2 | 199 | 92 | 84 | 24 | 84 | 151 | 22 | 0 | 0 | 4 | 19 | 8 | 1 | 4.10 |
| SP | Johnson, S.Johnson, Steve >> | 24 | 2012 | R | 72 | 30 | 30 | 6 | 3 | 2.71 | .314 | 1.35 | 6.0 | 6.1 | 9.3 | 133.0 | 89 | 44 | 40 | 7 | 90 | 138 | 0 | 0 | 0 | 0 | 2 | 4 | 3 | 3.73 |
| SP | Rogers, T.Rogers, Trevor >> | 27 | 2025 | L | 89 | 28 | 28 | 11 | 11 | 3.69 | .286 | 1.19 | 8.0 | 2.7 | 5.8 | 197.2 | 175 | 89 | 81 | 23 | 60 | 126 | 5 | 0 | 0 | 0 | 19 | 3 | 0 | 4.20 |
| SP | Wilhelm, H.Wilhelm, Hoyt >> | 36 | 1958 | R | 93 | 25 | 25 | 0 | 6 | 4.72 | .335 | 1.50 | 9.5 | 4.0 | 5.9 | 82.0 | 87 | 46 | 43 | 9 | 36 | 54 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.46 |
| RP | Britton, Z.Britton, Zach >> | 26 | 2014 | L | 60 | 82 | 0 | 9 | 4 | 3.40 | .287 | 1.21 | 7.8 | 3.1 | 5.7 | 82.0 | 71 | 39 | 31 | 10 | 28 | 52 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 4.34 |
| RP | Uehara, K.Uehara, Koji >> | 36 | 2011 | R | 94 | 78 | 0 | 13 | 1 | 3.52 | .266 | 1.08 | 7.2 | 2.4 | 9.4 | 92.0 | 74 | 39 | 36 | 9 | 25 | 96 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.03 |
| RP | Bautista, F.Bautista, Felix >> | 28 | 2023 | R | 81 | 77 | 0 | 10 | 1 | 3.07 | .287 | 1.18 | 5.2 | 5.4 | 9.0 | 76.1 | 44 | 28 | 26 | 3 | 46 | 76 | 0 | 3 | 2 | 0 | 0 | 2 | 6 | 3.41 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 33 | 1968 | R | 48 | 70 | 0 | 6 | 4 | 3.77 | .322 | 1.41 | 8.3 | 4.5 | 6.4 | 76.1 | 70 | 38 | 32 | 7 | 38 | 54 | 0 | 4 | 1 | 0 | 0 | 1 | 8 | 4.32 |
| RP | Orosco, J.Orosco, Jesse >> | 38 | 1995 | L | 44 | 68 | 0 | 3 | 4 | 5.68 | .337 | 1.52 | 7.6 | 6.1 | 6.9 | 65.0 | 55 | 45 | 41 | 14 | 44 | 50 | 0 | 8 | 5 | 0 | 0 | 0 | 3 | 6.29 |