| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 84 | 31 | 31 | 10 | 13 | 5.54 | .318 | 1.40 | 10.0 | 2.6 | 8.3 | 201.1 | 224 | 135 | 124 | 39 | 58 | 186 | 2 | 0 | 0 | 1 | 14 | 0 | 6 | 4.54 |
| SP | Verlander, J.Verlander, Justin >> | 33 | 2016 | R | 51 | 30 | 30 | 6 | 20 | 5.44 | .356 | 1.65 | 11.2 | 3.6 | 7.7 | 197.0 | 246 | 132 | 119 | 29 | 79 | 169 | 3 | 0 | 0 | 1 | 11 | 2 | 3 | 4.43 |
| SP | Scherzer, M.Scherzer, Max # >> | 29 | 2013 | R | 77 | 30 | 30 | 8 | 12 | 5.68 | .339 | 1.52 | 10.5 | 3.2 | 7.9 | 198.0 | 230 | 127 | 125 | 26 | 70 | 173 | 2 | 0 | 0 | 0 | 11 | 4 | 3 | 4.08 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 66 | 29 | 29 | 10 | 11 | 5.56 | .321 | 1.40 | 9.8 | 2.8 | 8.4 | 171.2 | 187 | 114 | 106 | 30 | 54 | 160 | 0 | 0 | 0 | 0 | 12 | 3 | 6 | 4.41 |
| SP | Wilson, E.Wilson, Earl >> | 32 | 1966 | R | 44 | 28 | 28 | 12 | 13 | 5.04 | .330 | 1.45 | 10.4 | 2.7 | 4.4 | 203.2 | 235 | 121 | 114 | 29 | 60 | 99 | 5 | 0 | 0 | 0 | 12 | 6 | 2 | 4.86 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 80 | 78 | 0 | 7 | 3 | 2.81 | .292 | 1.22 | 7.1 | 3.9 | 9.0 | 102.2 | 81 | 36 | 32 | 12 | 44 | 102 | 0 | 6 | 7 | 0 | 0 | 2 | 0 | 3.88 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 69 | 66 | 0 | 6 | 1 | 3.55 | .285 | 1.18 | 6.7 | 4.0 | 8.7 | 78.2 | 58 | 31 | 31 | 11 | 35 | 75 | 0 | 9 | 1 | 0 | 0 | 1 | 4 | 4.29 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 49 | 48 | 0 | 6 | 5 | 3.06 | .282 | 1.16 | 6.5 | 4.0 | 9.7 | 50.0 | 36 | 19 | 17 | 5 | 22 | 54 | 0 | 9 | 2 | 0 | 0 | 1 | 1 | 3.52 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 58 | 27 | 0 | 1 | 0 | 3.74 | .253 | 1.02 | 6.9 | 2.6 | 8.6 | 21.2 | 16 | 9 | 9 | 4 | 6 | 20 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 4.43 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 33 | 11 | 0 | 1 | 1 | 1.84 | .170 | 0.61 | 5.1 | 0.6 | 5.8 | 14.2 | 8 | 3 | 3 | 1 | 1 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.86 |
| RP | Jimenez, J.Jimenez, Joe >> | 27 | 2022 | R | 31 | 16 | 0 | 0 | 1 | 4.22 | .347 | 1.59 | 12.4 | 2.1 | 8.6 | 21.1 | 29 | 10 | 10 | 3 | 5 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.67 |