| SP | Scherzer, M.Scherzer, Max >> | 39 | 2023 | R | 93 | 17 | 17 | 0 | 2 | 3.77 | .299 | 1.28 | 7.7 | 3.8 | 8.0 | 43.0 | 37 | 19 | 18 | 4 | 18 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.70 |
| SP | Eovaldi, N.Eovaldi, Nathan >> | 35 | 2025 | R | 94 | 17 | 17 | 9 | 6 | 3.99 | .287 | 1.21 | 7.8 | 3.1 | 6.2 | 103.2 | 89 | 48 | 46 | 7 | 36 | 71 | 1 | 0 | 0 | 0 | 9 | 0 | 5 | 3.55 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 74 | 16 | 16 | 4 | 7 | 5.68 | .357 | 1.65 | 10.0 | 4.9 | 8.8 | 84.0 | 93 | 56 | 53 | 16 | 46 | 82 | 0 | 0 | 0 | 0 | 6 | 1 | 3 | 5.20 |
| SP | deGrom, J.deGrom, Jacob >> | 35 | 2023 | R | 99 | 16 | 16 | 0 | 3 | 3.67 | .282 | 1.18 | 8.1 | 2.6 | 8.8 | 41.2 | 37 | 17 | 17 | 8 | 12 | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.46 |
| RP | Soria, J.Soria, Joakim † >> | 30 | 2014 | R | 63 | 43 | 0 | 9 | 1 | 3.31 | .297 | 1.23 | 8.5 | 2.7 | 9.2 | 54.1 | 51 | 25 | 20 | 5 | 16 | 55 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.17 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 98 | 42 | 0 | 6 | 1 | 1.66 | .243 | 0.96 | 5.3 | 3.3 | 8.9 | 76.0 | 45 | 14 | 14 | 6 | 28 | 75 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 3.16 |
| RP | Armstrong, S.Armstrong, Shawn >> | 34 | 2025 | R | 82 | 39 | 0 | 2 | 1 | 1.96 | .270 | 1.05 | 6.7 | 2.8 | 7.7 | 55.0 | 41 | 17 | 12 | 2 | 17 | 47 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 2.85 |
| RP | Leclerc, J.Leclerc, Jose >> | 24 | 2018 | R | 85 | 22 | 0 | 0 | 2 | 3.04 | .298 | 1.28 | 8.0 | 3.8 | 9.0 | 26.2 | 23 | 11 | 9 | 3 | 11 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.77 |
| RP | Robertson, D.Robertson, David >> | 39 | 2024 | R | 50 | 18 | 0 | 1 | 1 | 2.53 | .304 | 1.31 | 8.6 | 3.4 | 12.0 | 21.1 | 20 | 7 | 6 | 1 | 8 | 28 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 2.10 |
| RP | Uehara, K.Uehara, Koji >> | 37 | 2012 | R | 93 | 18 | 0 | 1 | 1 | 1.40 | .222 | 0.86 | 6.1 | 1.8 | 11.5 | 25.2 | 17 | 5 | 4 | 2 | 5 | 32 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.08 |