| SP | Johnson, W.Johnson, Walter † >> | 26 | 1913 | R | 95 | 23 | 23 | 13 | 6 | 2.74 | .271 | 1.11 | 8.3 | 1.7 | 4.0 | 167.1 | 154 | 65 | 51 | 13 | 32 | 74 | 3 | 0 | 0 | 2 | 19 | 1 | 3 | 3.72 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 22 | 22 | 5 | 12 | 6.56 | .360 | 1.68 | 11.9 | 3.2 | 8.8 | 118.0 | 156 | 93 | 86 | 16 | 42 | 116 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 3.89 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 21 | 21 | 9 | 9 | 4.10 | .314 | 1.35 | 9.5 | 2.7 | 4.1 | 138.1 | 146 | 71 | 63 | 15 | 41 | 63 | 3 | 0 | 0 | 1 | 12 | 3 | 4 | 4.46 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 21 | 21 | 6 | 11 | 5.02 | .316 | 1.37 | 9.9 | 2.4 | 5.7 | 138.0 | 152 | 86 | 77 | 22 | 37 | 87 | 3 | 0 | 0 | 0 | 10 | 2 | 3 | 4.66 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 49 | 0 | 1 | 1 | 4.85 | .287 | 1.21 | 8.5 | 2.3 | 7.8 | 39.0 | 37 | 22 | 21 | 8 | 10 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.69 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 49 | 0 | 3 | 1 | 4.03 | .288 | 1.18 | 8.1 | 2.6 | 8.3 | 38.0 | 34 | 18 | 17 | 5 | 11 | 35 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 3.82 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 29 | 0 | 4 | 2 | 1.98 | .261 | 1.06 | 7.3 | 2.3 | 6.7 | 27.1 | 22 | 7 | 6 | 2 | 7 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.26 |
| RP | Radatz, D.Radatz, Dick >> | 26 | 1963 | R | 19 | 34 | 0 | 0 | 1 | 6.71 | .385 | 1.86 | 12.2 | 4.8 | 8.3 | 53.2 | 72 | 47 | 40 | 9 | 28 | 49 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.00 |
| SU | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 32 | 0 | 0 | 0 | 3.49 | .274 | 1.13 | 8.0 | 2.3 | 7.7 | 28.1 | 25 | 12 | 11 | 3 | 7 | 24 | 0 | 1 | 3 | 0 | 0 | 0 | 3 | 3.43 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 37 | 0 | 0 | 3 | 2.61 | .278 | 1.16 | 7.8 | 2.6 | 8.1 | 38.0 | 33 | 11 | 11 | 3 | 11 | 34 | 0 | 26 | 3 | 0 | 0 | 0 | 0 | 3.11 |