| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 25 | 25 | 7 | 14 | 3.90 | .282 | 1.16 | 8.1 | 2.3 | 9.1 | 168.2 | 152 | 75 | 73 | 12 | 43 | 169 | 1 | 0 | 0 | 0 | 13 | 4 | 0 | 2.76 |
| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 24 | 24 | 10 | 11 | 4.60 | .311 | 1.31 | 9.1 | 2.7 | 8.3 | 189.2 | 191 | 101 | 97 | 20 | 57 | 175 | 7 | 0 | 0 | 0 | 9 | 9 | 3 | 3.57 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 23 | 23 | 8 | 9 | 5.02 | .333 | 1.48 | 9.6 | 3.7 | 4.9 | 141.2 | 151 | 83 | 79 | 19 | 58 | 76 | 0 | 0 | 0 | 0 | 10 | 3 | 5 | 4.97 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 68 | 0 | 2 | 2 | 3.79 | .261 | 1.04 | 7.6 | 1.8 | 8.2 | 59.1 | 50 | 25 | 25 | 8 | 12 | 54 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 3.59 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 49 | 0 | 3 | 6 | 3.22 | .241 | 0.95 | 6.3 | 2.3 | 9.2 | 50.1 | 35 | 19 | 18 | 7 | 13 | 51 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 25 | 0 | 2 | 2 | 3.97 | .320 | 1.41 | 9.8 | 3.3 | 9.0 | 22.2 | 24 | 10 | 10 | 2 | 8 | 22 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.27 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 2 | 0 | 0 | 0 | 0.00 | .385 | 1.88 | 18.0 | 4.5 | 9.0 | 2.2 | 4 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.50 |