| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 35 | 35 | 14 | 14 | 4.32 | .297 | 1.23 | 8.8 | 2.3 | 8.5 | 195.2 | 190 | 97 | 94 | 24 | 50 | 184 | 3 | 0 | 0 | 2 | 19 | 8 | 1 | 3.61 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 34 | 34 | 19 | 6 | 3.97 | .299 | 1.25 | 8.1 | 3.2 | 4.4 | 197.0 | 177 | 95 | 87 | 16 | 70 | 97 | 1 | 0 | 0 | 1 | 18 | 5 | 5 | 4.21 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 30 | 30 | 12 | 8 | 4.02 | .324 | 1.42 | 7.9 | 4.8 | 9.1 | 143.1 | 126 | 67 | 64 | 12 | 77 | 145 | 0 | 0 | 0 | 0 | 7 | 3 | 3 | 3.74 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 98 | 0 | 8 | 4 | 3.71 | .301 | 1.26 | 6.5 | 4.9 | 10.2 | 116.1 | 84 | 50 | 48 | 18 | 63 | 132 | 0 | 2 | 3 | 0 | 0 | 3 | 7 | 4.45 |
| RP | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 97 | 0 | 7 | 1 | 3.04 | .289 | 1.17 | 8.9 | 1.7 | 8.0 | 100.2 | 99 | 38 | 34 | 9 | 19 | 89 | 0 | 7 | 0 | 0 | 0 | 5 | 0 | 3.11 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 78 | 0 | 5 | 1 | 3.32 | .278 | 1.13 | 7.2 | 3.0 | 5.4 | 84.0 | 67 | 34 | 31 | 11 | 28 | 50 | 0 | 12 | 3 | 0 | 0 | 2 | 0 | 4.58 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 31 | 111 | 0 | 1 | 3 | 3.46 | .300 | 1.26 | 5.2 | 6.2 | 8.2 | 75.1 | 43 | 30 | 29 | 4 | 52 | 68 | 0 | 9 | 1 | 0 | 0 | 2 | 0 | 4.04 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 72 | 0 | 1 | 4 | 3.52 | .289 | 1.22 | 6.5 | 4.5 | 8.2 | 46.0 | 33 | 18 | 18 | 5 | 23 | 42 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 4.09 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 62 | 0 | 6 | 3 | 1.94 | .271 | 1.10 | 4.2 | 5.6 | 9.4 | 51.0 | 24 | 14 | 11 | 4 | 32 | 53 | 0 | 9 | 3 | 0 | 0 | 1 | 4 | 3.88 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 53 | 0 | 5 | 2 | 4.04 | .325 | 1.42 | 8.0 | 4.8 | 5.9 | 93.2 | 83 | 50 | 42 | 11 | 50 | 61 | 0 | 6 | 0 | 0 | 0 | 2 | 1 | 4.90 |