| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 23 | 23 | 4 | 15 | 4.71 | .325 | 1.44 | 8.6 | 4.4 | 8.0 | 151.0 | 144 | 81 | 79 | 15 | 73 | 134 | 1 | 0 | 0 | 0 | 14 | 1 | 2 | 3.99 |
| SP | Walsh, E.Walsh, Ed † # >> | 29 | 1910 | R | 93 | 22 | 22 | 12 | 9 | 4.31 | .288 | 1.18 | 8.5 | 2.1 | 3.5 | 177.1 | 168 | 90 | 85 | 21 | 42 | 68 | 14 | 0 | 0 | 1 | 10 | 5 | 4 | 4.57 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 21 | 21 | 11 | 9 | 4.16 | .308 | 1.33 | 8.8 | 3.2 | 4.8 | 166.2 | 163 | 80 | 77 | 17 | 59 | 89 | 11 | 0 | 0 | 0 | 11 | 1 | 3 | 4.34 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 21 | 21 | 6 | 7 | 4.70 | .329 | 1.46 | 9.1 | 4.1 | 5.5 | 149.1 | 150 | 81 | 78 | 19 | 68 | 91 | 2 | 0 | 0 | 1 | 10 | 2 | 2 | 4.85 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 58 | 0 | 3 | 5 | 3.03 | .266 | 1.08 | 7.5 | 2.2 | 9.2 | 74.1 | 62 | 28 | 25 | 8 | 18 | 76 | 0 | 11 | 1 | 0 | 0 | 1 | 0 | 3.12 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 14 | 0 | 1 | 1 | 4.80 | .328 | 1.40 | 10.2 | 2.4 | 10.8 | 15.0 | 17 | 8 | 8 | 3 | 4 | 18 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.20 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 6 | 0 | 1 | 1 | 7.94 | .370 | 1.76 | 7.2 | 10.8 | 10.8 | 5.2 | 4 | 5 | 5 | 2 | 6 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 9.40 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 12 | 0 | 0 | 0 | 3.57 | .284 | 1.19 | 7.4 | 3.7 | 7.4 | 17.2 | 14 | 7 | 7 | 4 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.65 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 2 | 0 | 1 | 0 | 7.71 | .222 | 0.86 | 9.0 | 0.0 | 4.5 | 2.1 | 2 | 2 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.50 |