| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 34 | 34 | 12 | 17 | 4.97 | .315 | 1.35 | 9.0 | 3.1 | 7.6 | 249.2 | 249 | 144 | 138 | 32 | 87 | 210 | 9 | 0 | 0 | 0 | 13 | 8 | 3 | 4.13 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 33 | 33 | 13 | 13 | 3.70 | .294 | 1.23 | 7.5 | 3.6 | 9.5 | 223.2 | 185 | 104 | 92 | 24 | 90 | 235 | 1 | 0 | 0 | 1 | 22 | 4 | 4 | 3.56 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 32 | 32 | 12 | 12 | 4.51 | .317 | 1.37 | 9.4 | 3.0 | 4.4 | 227.1 | 237 | 121 | 114 | 26 | 75 | 111 | 2 | 0 | 0 | 0 | 15 | 4 | 1 | 4.56 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 31 | 31 | 8 | 15 | 5.90 | .354 | 1.63 | 10.8 | 3.9 | 7.6 | 207.1 | 248 | 141 | 136 | 34 | 90 | 174 | 3 | 0 | 0 | 0 | 9 | 3 | 5 | 4.80 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 88 | 0 | 4 | 3 | 2.45 | .282 | 1.18 | 7.1 | 3.6 | 8.5 | 113.2 | 89 | 31 | 31 | 10 | 45 | 107 | 0 | 10 | 3 | 0 | 0 | 0 | 4 | 3.45 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 70 | 0 | 8 | 6 | 3.86 | .328 | 1.42 | 8.1 | 4.8 | 6.4 | 79.1 | 71 | 36 | 34 | 9 | 42 | 56 | 0 | 8 | 1 | 0 | 0 | 3 | 0 | 4.77 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 20 | 0 | 3 | 0 | 3.24 | .348 | 1.60 | 7.6 | 6.8 | 8.6 | 25.0 | 21 | 11 | 9 | 5 | 19 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.96 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 61 | 25 | 0 | 0 | 0 | 3.49 | .331 | 1.48 | 9.6 | 3.9 | 7.4 | 28.1 | 30 | 13 | 11 | 4 | 12 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |