| SP | Lundgren, C.Lundgren, Carl † >> | 27 | 1907 | R | 43 | 24 | 24 | 11 | 8 | 3.21 | .297 | 1.27 | 7.1 | 4.4 | 4.7 | 173.2 | 136 | 64 | 62 | 10 | 84 | 91 | 3 | 0 | 0 | 2 | 18 | 0 | 4 | 4.16 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 24 | 24 | 4 | 13 | 4.36 | .332 | 1.48 | 9.8 | 3.5 | 6.7 | 165.0 | 179 | 81 | 80 | 19 | 65 | 123 | 1 | 0 | 0 | 0 | 13 | 2 | 2 | 4.22 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 23 | 23 | 12 | 4 | 3.86 | .292 | 1.23 | 8.8 | 2.3 | 4.6 | 168.0 | 164 | 75 | 72 | 14 | 42 | 85 | 2 | 0 | 0 | 0 | 15 | 2 | 1 | 3.86 |
| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 20 | 20 | 9 | 6 | 3.70 | .276 | 1.14 | 8.0 | 2.2 | 8.1 | 146.0 | 130 | 61 | 60 | 17 | 36 | 131 | 4 | 0 | 0 | 2 | 11 | 1 | 1 | 3.48 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 60 | 0 | 4 | 2 | 2.28 | .222 | 0.83 | 6.1 | 1.5 | 8.8 | 43.1 | 29 | 13 | 11 | 4 | 7 | 42 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 2.81 |
| CL | Balfour, G.Balfour, Grant † >> | 31 | 2008 | R | 76 | 41 | 0 | 2 | 3 | 3.28 | .291 | 1.23 | 6.9 | 4.4 | 8.7 | 35.2 | 27 | 15 | 13 | 2 | 17 | 34 | 0 | 27 | 4 | 0 | 0 | 0 | 2 | 3.26 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 53 | 0 | 4 | 2 | 2.40 | .271 | 1.11 | 7.7 | 2.4 | 7.9 | 41.1 | 35 | 12 | 11 | 1 | 11 | 36 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.37 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 31 | 0 | 3 | 1 | 2.33 | .216 | 0.78 | 5.7 | 1.4 | 5.2 | 19.1 | 12 | 5 | 5 | 2 | 3 | 11 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 3.84 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 16 | 11 | 2 | 3 | 4.09 | .302 | 1.30 | 6.9 | 4.9 | 7.7 | 61.2 | 47 | 29 | 28 | 4 | 33 | 52 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.77 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 27 | 0 | 1 | 2 | 4.81 | .342 | 1.52 | 7.5 | 6.4 | 9.0 | 24.1 | 20 | 18 | 13 | 2 | 17 | 24 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.33 |