| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 21 | 21 | 10 | 5 | 3.41 | .316 | 1.36 | 6.3 | 6.0 | 4.1 | 140.0 | 98 | 59 | 53 | 10 | 93 | 64 | 0 | 0 | 0 | 0 | 15 | 3 | 1 | 5.07 |
| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 22 | 22 | 15 | 5 | 3.05 | .274 | 1.12 | 7.7 | 2.5 | 6.8 | 174.1 | 148 | 64 | 59 | 18 | 48 | 132 | 6 | 0 | 0 | 3 | 16 | 1 | 2 | 3.67 |
| SP | Alexander, P.Alexander, Pete # >> | 28 | 1915 | R | 88 | 21 | 21 | 11 | 4 | 3.74 | .274 | 1.11 | 7.9 | 2.2 | 4.3 | 170.2 | 149 | 72 | 71 | 22 | 41 | 81 | 4 | 0 | 0 | 1 | 12 | 3 | 4 | 4.51 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 20 | 18 | 8 | 7 | 5.28 | .323 | 1.43 | 9.6 | 3.2 | 5.0 | 133.0 | 142 | 82 | 78 | 20 | 48 | 74 | 2 | 0 | 0 | 0 | 10 | 0 | 1 | 4.92 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 24 | 0 | 1 | 0 | 1.89 | .313 | 1.32 | 9.9 | 1.9 | 9.9 | 19.0 | 21 | 8 | 4 | 4 | 4 | 21 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.32 |
| CL | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 20 | 0 | 0 | 1 | 1.89 | .296 | 1.26 | 5.7 | 5.7 | 8.5 | 19.0 | 12 | 4 | 4 | 0 | 12 | 18 | 0 | 8 | 2 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 33 | 0 | 0 | 1 | 3.04 | .304 | 1.31 | 10.2 | 2.0 | 7.4 | 23.2 | 26 | 11 | 8 | 1 | 5 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.57 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 39 | 0 | 3 | 3 | 4.55 | .291 | 1.12 | 8.0 | 2.3 | 5.7 | 27.2 | 24 | 16 | 14 | 4 | 7 | 17 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 4.78 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 26 | 0 | 1 | 3 | 7.79 | .381 | 1.85 | 12.2 | 4.8 | 10.6 | 17.1 | 23 | 16 | 15 | 2 | 9 | 20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.76 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 5 | 4 | 2 | 3 | 4.88 | .299 | 1.21 | 8.1 | 2.9 | 5.2 | 31.1 | 28 | 18 | 17 | 7 | 10 | 18 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 5.94 |