| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 38 | 38 | 16 | 11 | 3.17 | .273 | 1.11 | 7.0 | 3.0 | 7.5 | 284.1 | 220 | 102 | 100 | 21 | 96 | 238 | 4 | 0 | 0 | 1 | 26 | 5 | 2 | 3.35 |
| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 19 | 9 | 3.41 | .282 | 1.15 | 8.2 | 2.3 | 8.4 | 234.2 | 212 | 89 | 89 | 33 | 59 | 219 | 1 | 0 | 0 | 0 | 24 | 6 | 0 | 3.79 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 34 | 34 | 16 | 13 | 3.71 | .303 | 1.28 | 7.2 | 4.4 | 4.0 | 252.0 | 201 | 110 | 104 | 17 | 122 | 112 | 6 | 0 | 0 | 1 | 18 | 5 | 2 | 4.50 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 102 | 0 | 3 | 5 | 3.28 | .275 | 1.08 | 7.1 | 2.6 | 7.1 | 68.2 | 54 | 26 | 25 | 6 | 20 | 54 | 0 | 1 | 1 | 0 | 0 | 4 | 1 | 3.62 |
| CL | Hoffman, T.Hoffman, Trevor † >> | 31 | 1998 | R | 75 | 59 | 0 | 1 | 3 | 2.80 | .251 | 0.97 | 6.0 | 2.8 | 8.0 | 54.2 | 36 | 17 | 17 | 3 | 17 | 48 | 0 | 51 | 5 | 0 | 0 | 2 | 2 | 3.00 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 55 | 0 | 4 | 4 | 1.08 | .209 | 0.74 | 4.6 | 2.2 | 7.5 | 41.2 | 21 | 5 | 5 | 2 | 10 | 34 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.85 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 22 | 0 | 5 | 1 | 1.77 | .247 | 0.93 | 7.2 | 1.4 | 6.3 | 20.1 | 16 | 4 | 4 | 1 | 3 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.85 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 13 | 0 | 0 | 1 | 3.27 | .327 | 1.45 | 8.2 | 4.9 | 9.0 | 11.0 | 10 | 4 | 4 | 3 | 6 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.18 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 71 | 0 | 2 | 3 | 4.15 | .257 | 1.04 | 6.3 | 3.1 | 11.1 | 43.1 | 30 | 21 | 20 | 8 | 15 | 53 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 4.00 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 50 | 2 | 0 | 0 | 0 | 0.00 | .053 | 0.17 | 1.5 | 0.0 | 6.0 | 6.0 | 1 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.67 |