| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 98 | 21 | 21 | 8 | 8 | 3.47 | .288 | 1.16 | 6.8 | 3.6 | 9.8 | 140.0 | 106 | 60 | 54 | 22 | 56 | 153 | 0 | 0 | 0 | 0 | 14 | 8 | 6 | 4.23 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 82 | 20 | 20 | 8 | 7 | 5.15 | .314 | 1.34 | 8.7 | 3.3 | 6.8 | 129.1 | 125 | 83 | 74 | 28 | 48 | 98 | 1 | 0 | 0 | 0 | 8 | 5 | 5 | 5.53 |
| SP | Darvish, Y.Darvish, Yu † >> | 26 | 2013 | R | 80 | 20 | 20 | 14 | 6 | 3.10 | .289 | 1.20 | 7.1 | 3.7 | 9.7 | 136.2 | 108 | 50 | 47 | 13 | 56 | 147 | 1 | 0 | 0 | 1 | 14 | 3 | 2 | 3.38 |
| SP | Richards, G.Richards, Garrett >> | 26 | 2014 | R | 76 | 20 | 20 | 8 | 9 | 4.64 | .310 | 1.31 | 8.4 | 3.3 | 7.8 | 130.0 | 122 | 70 | 67 | 16 | 48 | 112 | 2 | 0 | 0 | 1 | 8 | 5 | 6 | 4.10 |
| SP | Bauer, T.Bauer, Trevor † >> | 27 | 2018 | R | 60 | 19 | 19 | 12 | 3 | 4.21 | .312 | 1.34 | 8.8 | 3.3 | 8.9 | 119.2 | 116 | 59 | 56 | 17 | 44 | 118 | 1 | 0 | 0 | 1 | 12 | 3 | 2 | 4.06 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 53 | 0 | 2 | 1 | 3.84 | .335 | 1.44 | 8.1 | 4.9 | 10.9 | 61.0 | 55 | 26 | 26 | 9 | 33 | 74 | 0 | 1 | 0 | 0 | 0 | 4 | 3 | 4.31 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 87 | 45 | 0 | 5 | 3 | 3.61 | .266 | 1.09 | 6.9 | 2.9 | 11.3 | 52.1 | 40 | 21 | 21 | 5 | 17 | 65 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.73 |
| RP | Holland, G.Holland, Greg # >> | 27 | 2013 | R | 74 | 35 | 0 | 1 | 1 | 4.63 | .318 | 1.37 | 8.5 | 3.9 | 13.1 | 35.0 | 33 | 18 | 18 | 8 | 15 | 51 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.43 |
| RP | Balfour, G.Balfour, Grant >> | 35 | 2012 | R | 60 | 32 | 0 | 1 | 0 | 2.95 | .286 | 1.20 | 7.8 | 3.3 | 7.8 | 36.2 | 31 | 13 | 12 | 5 | 13 | 31 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.17 |
| CL | Siegrist, K.Siegrist, Kevin † >> | 23 | 2013 | L | 78 | 46 | 0 | 1 | 1 | 3.76 | .295 | 1.25 | 6.3 | 5.2 | 12.6 | 40.2 | 28 | 21 | 17 | 2 | 23 | 56 | 0 | 30 | 1 | 0 | 0 | 0 | 0 | 2.58 |
| SP | Sanchez, A.Sanchez, Anibal >> | 34 | 2018 | R | 52 | 6 | 0 | 0 | 1 | 2.25 | .308 | 1.33 | 9.8 | 2.3 | 5.3 | 12.0 | 13 | 3 | 3 | 1 | 3 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.67 |