| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 100 | 9 | 9 | 3 | 5 | 4.44 | .315 | 1.38 | 9.7 | 2.9 | 9.2 | 50.2 | 54 | 25 | 25 | 3 | 16 | 51 | 0 | 0 | 0 | 0 | 5 | 0 | 2 | 2.70 |
| SP | Thompson, J.Thompson, Justin >> | 25 | 1998 | L | 49 | 8 | 8 | 3 | 5 | 3.38 | .312 | 1.32 | 8.8 | 3.2 | 5.9 | 50.2 | 49 | 25 | 19 | 4 | 18 | 33 | 1 | 0 | 0 | 1 | 6 | 2 | 1 | 3.92 |
| SP | Mussina, M.Mussina, Mike # >> | 28 | 1996 | R | 45 | 8 | 8 | 2 | 3 | 5.06 | .366 | 1.71 | 12.0 | 3.4 | 5.8 | 48.0 | 64 | 31 | 27 | 7 | 18 | 31 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.79 |
| RP | Orosco, J.Orosco, Jesse >> | 32 | 1989 | L | 98 | 24 | 0 | 1 | 0 | 1.65 | .269 | 1.10 | 6.5 | 3.7 | 8.7 | 32.2 | 23 | 8 | 6 | 1 | 13 | 31 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 2.69 |
| RP | Nelson, G.Nelson, Gene >> | 30 | 1990 | R | 90 | 21 | 0 | 2 | 1 | 2.48 | .210 | 0.73 | 5.1 | 1.7 | 6.5 | 32.2 | 18 | 9 | 9 | 1 | 6 | 23 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.72 |
| RP | Walden, J.Walden, Jordan >> | 26 | 2014 | R | 88 | 16 | 0 | 1 | 1 | 3.93 | .360 | 1.69 | 8.0 | 7.5 | 8.5 | 18.1 | 16 | 9 | 8 | 3 | 15 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.78 |
| RP | Ramirez, R.Ramirez, Ramon >> | 30 | 2011 | R | 73 | 17 | 0 | 1 | 0 | 1.33 | .291 | 1.23 | 7.7 | 3.6 | 7.7 | 20.1 | 17 | 3 | 3 | 1 | 8 | 17 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.15 |
| RP | Karinchak, J.Karinchak, James >> | 27 | 2023 | R | 68 | 10 | 0 | 0 | 1 | 6.00 | .368 | 1.67 | 8.3 | 6.8 | 7.5 | 12.0 | 11 | 10 | 8 | 0 | 9 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.83 |
| RP | Nicolas, K.Nicolas, Kyle >> | 26 | 2025 | R | 40 | 11 | 0 | 1 | 0 | 2.63 | .328 | 1.46 | 10.4 | 3.5 | 4.8 | 13.2 | 15 | 4 | 4 | 1 | 5 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.08 |
| SP | McGregor, S.McGregor, Scott >> | 30 | 1984 | L | 35 | 7 | 0 | 0 | 1 | 1.54 | .314 | 1.37 | 9.0 | 4.1 | 2.5 | 11.2 | 11 | 2 | 2 | 0 | 5 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.82 |