| SP | Santana, J.Santana, Johan >> | 26 | 2005 | L | 99 | 23 | 23 | 11 | 5 | 3.06 | .271 | 1.11 | 8.0 | 2.0 | 7.8 | 161.2 | 143 | 56 | 55 | 8 | 36 | 140 | 3 | 0 | 0 | 3 | 17 | 1 | 6 | 2.60 |
| SP | Urquidy, J.Urquidy, Jose >> | 27 | 2022 | R | 75 | 23 | 23 | 11 | 9 | 4.43 | .297 | 1.26 | 8.9 | 2.4 | 5.0 | 126.0 | 125 | 63 | 62 | 14 | 34 | 70 | 1 | 0 | 0 | 1 | 12 | 1 | 3 | 4.17 |
| SP | Pearson, M.Pearson, Monte >> | 28 | 1936 | R | 44 | 23 | 21 | 5 | 8 | 5.22 | .341 | 1.52 | 8.2 | 5.5 | 4.0 | 129.1 | 117 | 75 | 75 | 10 | 79 | 58 | 2 | 0 | 1 | 1 | 9 | 5 | 6 | 5.06 |
| CL | Isringhausen, J.Isringhausen, Jason † >> | 30 | 2002 | R | 94 | 41 | 0 | 5 | 5 | 3.00 | .311 | 1.33 | 8.4 | 3.6 | 6.4 | 45.0 | 42 | 17 | 15 | 1 | 18 | 32 | 0 | 19 | 2 | 0 | 0 | 1 | 0 | 3.13 |
| RP | Quantrill, P.Quantrill, Paul >> | 33 | 2001 | R | 47 | 47 | 0 | 1 | 3 | 3.70 | .303 | 1.29 | 9.5 | 2.1 | 6.3 | 56.0 | 59 | 30 | 23 | 5 | 13 | 39 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.52 |
| SU | Burgmeier, T.Burgmeier, Tom >> | 39 | 1982 | L | 52 | 53 | 0 | 1 | 0 | 2.40 | .248 | 0.99 | 7.3 | 1.7 | 4.3 | 63.2 | 51 | 17 | 17 | 3 | 12 | 30 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.24 |
| RP | Brigham, J.Brigham, Jeff # >> | 27 | 2019 | R | 43 | 39 | 0 | 1 | 4 | 7.46 | .379 | 1.83 | 12.1 | 4.4 | 9.9 | 41.0 | 55 | 37 | 34 | 7 | 20 | 45 | 0 | 0 | 5 | 0 | 0 | 0 | 8 | 4.49 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 91 | 21 | 21 | 10 | 8 | 4.13 | .307 | 1.30 | 9.3 | 2.5 | 5.1 | 128.2 | 132 | 63 | 59 | 12 | 35 | 73 | 2 | 0 | 0 | 1 | 13 | 4 | 1 | 3.99 |
| SP | Leonard, D.Leonard, Dutch >> | 34 | 1943 | R | 58 | 23 | 6 | 4 | 4 | 4.84 | .318 | 1.39 | 9.7 | 2.8 | 3.4 | 102.1 | 110 | 62 | 55 | 8 | 32 | 38 | 3 | 0 | 0 | 0 | 4 | 1 | 5 | 4.25 |