| SP | Bielecki, M.Bielecki, Mike >> | 30 | 1989 | R | 76 | 16 | 16 | 7 | 6 | 4.32 | .310 | 1.30 | 7.5 | 4.2 | 4.7 | 100.0 | 83 | 53 | 48 | 8 | 47 | 52 | 2 | 0 | 0 | 1 | 9 | 5 | 4 | 4.56 |
| SP | Collins, R.Collins, Rip >> | 28 | 1924 | R | 72 | 15 | 15 | 5 | 6 | 6.40 | .371 | 1.76 | 12.7 | 3.1 | 5.0 | 83.0 | 117 | 65 | 59 | 8 | 29 | 46 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 4.23 |
| SP | Phillippe, D.Phillippe, Deacon >> | 35 | 1907 | R | 66 | 15 | 15 | 5 | 4 | 4.55 | .314 | 1.37 | 10.3 | 2.0 | 5.4 | 93.0 | 106 | 48 | 47 | 8 | 21 | 56 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 3.62 |
| SP | Osteen, C.Osteen, Claude >> | 27 | 1966 | L | 60 | 15 | 15 | 3 | 7 | 5.24 | .322 | 1.41 | 10.0 | 2.8 | 4.4 | 87.2 | 97 | 57 | 51 | 10 | 27 | 43 | 0 | 0 | 0 | 0 | 10 | 1 | 1 | 4.47 |
| SP | Buehrle, M.Buehrle, Mark >> | 25 | 2004 | L | 57 | 16 | 15 | 5 | 7 | 5.54 | .362 | 1.68 | 12.0 | 3.2 | 4.5 | 100.2 | 133 | 71 | 62 | 15 | 36 | 50 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 5.09 |
| CL | Sherrill, G.Sherrill, George >> | 30 | 2007 | L | 94 | 34 | 0 | 1 | 1 | 2.55 | .269 | 1.08 | 7.2 | 2.6 | 11.1 | 35.1 | 28 | 12 | 10 | 3 | 10 | 43 | 0 | 19 | 2 | 0 | 0 | 1 | 2 | 2.60 |
| SU | Nottebart, D.Nottebart, Don >> | 31 | 1967 | R | 59 | 38 | 0 | 1 | 3 | 3.99 | .324 | 1.44 | 10.0 | 3.1 | 6.5 | 47.1 | 52 | 21 | 21 | 6 | 16 | 34 | 0 | 4 | 0 | 0 | 0 | 0 | 3 | 4.23 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 37 | 2009 | R | 58 | 48 | 0 | 5 | 4 | 5.43 | .323 | 1.38 | 9.8 | 2.5 | 4.9 | 53.0 | 58 | 32 | 32 | 8 | 15 | 29 | 0 | 0 | 7 | 0 | 0 | 3 | 1 | 4.89 |
| RP | Patterson, D.Patterson, Danny >> | 30 | 2001 | R | 52 | 27 | 0 | 3 | 1 | 4.50 | .280 | 1.17 | 8.5 | 2.0 | 4.3 | 36.0 | 34 | 18 | 18 | 4 | 8 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.17 |