| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 32 | 32 | 10 | 11 | 3.49 | .282 | 1.17 | 7.3 | 3.3 | 9.1 | 208.2 | 168 | 84 | 81 | 19 | 76 | 210 | 0 | 0 | 0 | 0 | 19 | 2 | 0 | 3.29 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 85 | 31 | 31 | 11 | 15 | 5.16 | .307 | 1.31 | 8.7 | 3.2 | 7.7 | 188.1 | 181 | 115 | 108 | 32 | 66 | 160 | 0 | 0 | 0 | 0 | 15 | 3 | 5 | 4.61 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 31 | 31 | 16 | 9 | 4.31 | .331 | 1.46 | 9.8 | 3.3 | 4.6 | 221.1 | 241 | 119 | 106 | 25 | 82 | 112 | 5 | 0 | 0 | 0 | 17 | 6 | 8 | 4.65 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 31 | 31 | 10 | 12 | 4.73 | .334 | 1.49 | 9.4 | 4.0 | 4.9 | 215.0 | 225 | 122 | 113 | 27 | 95 | 117 | 3 | 0 | 0 | 1 | 16 | 3 | 6 | 4.91 |
| SP | Gooden, D.Gooden, Dwight # >> | 21 | 1985 | R | 68 | 30 | 30 | 12 | 10 | 4.85 | .318 | 1.37 | 9.4 | 2.9 | 6.4 | 200.1 | 209 | 117 | 108 | 21 | 65 | 142 | 3 | 0 | 0 | 1 | 17 | 6 | 4 | 4.01 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 84 | 0 | 6 | 6 | 3.74 | .273 | 1.08 | 6.7 | 3.0 | 8.1 | 113.0 | 84 | 55 | 47 | 21 | 38 | 102 | 0 | 8 | 8 | 0 | 0 | 5 | 3 | 4.75 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 78 | 0 | 3 | 2 | 2.86 | .263 | 1.05 | 7.2 | 2.3 | 7.8 | 100.2 | 80 | 38 | 32 | 12 | 26 | 87 | 0 | 12 | 4 | 0 | 0 | 2 | 3 | 3.66 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 55 | 0 | 3 | 3 | 4.55 | .308 | 1.30 | 9.2 | 2.6 | 10.0 | 55.1 | 56 | 29 | 28 | 9 | 16 | 61 | 0 | 6 | 0 | 0 | 0 | 2 | 1 | 3.89 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 27 | 0 | 4 | 3 | 2.88 | .326 | 1.43 | 7.2 | 5.9 | 10.1 | 40.2 | 32 | 16 | 13 | 3 | 26 | 45 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 3.75 |