| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 30 | 30 | 12 | 8 | 3.35 | .266 | 1.06 | 7.9 | 1.7 | 7.4 | 198.2 | 173 | 75 | 74 | 13 | 37 | 163 | 6 | 0 | 0 | 0 | 20 | 6 | 7 | 2.86 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 32 | 32 | 13 | 9 | 4.06 | .302 | 1.28 | 7.4 | 4.2 | 5.2 | 188.1 | 155 | 90 | 85 | 13 | 87 | 109 | 0 | 0 | 0 | 0 | 20 | 3 | 2 | 4.18 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 31 | 31 | 14 | 9 | 4.14 | .281 | 1.17 | 8.5 | 2.1 | 7.2 | 193.2 | 183 | 91 | 89 | 31 | 44 | 155 | 6 | 0 | 0 | 2 | 18 | 0 | 2 | 4.17 |
| SP | Cooper, M.Cooper, Mort >> | 29 | 1942 | R | 47 | 31 | 31 | 12 | 13 | 5.34 | .340 | 1.53 | 9.9 | 3.9 | 4.2 | 187.0 | 205 | 125 | 111 | 17 | 82 | 88 | 2 | 0 | 0 | 1 | 13 | 2 | 5 | 4.59 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 80 | 0 | 7 | 5 | 1.80 | .268 | 1.10 | 5.3 | 4.6 | 11.1 | 80.0 | 47 | 16 | 16 | 3 | 41 | 99 | 0 | 38 | 5 | 0 | 0 | 0 | 4 | 2.55 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 88 | 0 | 4 | 3 | 3.50 | .294 | 1.23 | 9.0 | 2.2 | 5.8 | 92.2 | 92 | 37 | 36 | 8 | 22 | 59 | 0 | 4 | 4 | 0 | 0 | 2 | 0 | 3.63 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 79 | 0 | 5 | 5 | 5.09 | .327 | 1.43 | 9.1 | 3.8 | 9.7 | 76.0 | 77 | 44 | 43 | 14 | 32 | 82 | 0 | 1 | 5 | 0 | 0 | 2 | 3 | 4.58 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 89 | 0 | 3 | 2 | 4.20 | .300 | 1.26 | 6.8 | 4.7 | 7.4 | 85.2 | 64 | 40 | 40 | 8 | 44 | 70 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 4.20 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 66 | 0 | 7 | 4 | 3.86 | .314 | 1.37 | 8.4 | 4.0 | 10.4 | 100.1 | 93 | 50 | 43 | 8 | 44 | 116 | 0 | 1 | 3 | 0 | 0 | 1 | 3 | 3.07 |